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UCHL3

GENERAL INFORMATION

Gene name

 UCHL3

Gene description

 Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA019678 , CAB037139 , CAB037208
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019678
CAB037139
CAB037208

GENE INFORMATION

Gene name

 UCHL3

Synonyms

Description

 Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Chromosome

 13

Cytoband

 q22.2

Chromosome location (bp)

 75549480 - 75606020

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118939 (version 83.38)

Entrez gene

 7347

UniProt

 P15374 (UniProt - Evidence at protein level)

neXtProt

 NX_P15374

Antibodypedia

 UCHL3 antibodies

PROTEIN BROWSER
UCHL3-001
UCHL3-003
UCHL3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UCHL3-001
ENSP00000366819
ENST00000377595
P15374 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L3
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008233 [peptidase activity]
GO:0016579 [protein deubiquitination]
GO:0030163 [protein catabolic process]
GO:0043130 [ubiquitin binding]
GO:0070062 [extracellular exosome]
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 230 aa
26.2 kDa 		No 0
UCHL3-003
ENSP00000398189
ENST00000419068
Q5TBK7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
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 228 aa
25.5 kDa 		No 0
UCHL3-201
ENSP00000477746
ENST00000618773
A0A087WTB8 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
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 194 aa
21.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.