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COIL

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GENERAL INFORMATION

Gene name

 COIL

Gene description

 Coilin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear bodies. In addition localized to the nucleus & nucleoli (fibrillar center).

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (validated)

Additional location

 In addition localized to the Nucleus (supported), Nucleoli fibrillar center (validated)

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
CAB017524 , HPA027885 , HPA068537
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear bodies. In addition localized to the nucleus & nucleoli (fibrillar center).

Main location

 Nuclear bodies (validated)

Additional location

 Nucleus (supported), Nucleoli fibrillar center (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB017524 A-431 Nucleus
Nucleoli fibrillar center
CAB017524 U-2 OS Nucleus
Nucleoli fibrillar center
CAB017524 U-251 MG Nuclear bodies
HPA027885 HEK 293 Nuclear bodies
HPA027885 MCF7 Nucleoli fibrillar center
HPA027885 U-2 OS Nucleus
Nucleoli fibrillar center
HPA068537 HEK 293 Nucleus
Nuclear bodies
HPA068537 SH-SY5Y Nucleus
Nuclear bodies
HPA068537 U-2 OS Nucleus

GENE INFORMATION

Gene name

 COIL (HGNC Symbol)

Synonyms

 CLN80, p80-coilin

Description

 Coilin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q22

Chromosome location (bp)

 56938187 - 56961054

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121058 (version 83.38)

Entrez gene

 8161

UniProt

 P38432 (UniProt - Evidence at protein level)

neXtProt

 NX_P38432

Antibodypedia

 COIL antibodies

PROTEIN BROWSER
COIL-001
COIL-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COIL-001
ENSP00000240316
ENST00000240316
P38432 [Direct mapping]
Coilin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001674 [female germ cell nucleus]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0008022 [protein C-terminus binding]
GO:0015030 [Cajal body]
GO:0015036 [disulfide oxidoreductase activity]
GO:0016020 [membrane]
GO:0042802 [identical protein binding]
GO:0055114 [oxidation-reduction process]
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 576 aa
62.6 kDa 		No 0
COIL-002
ENSP00000460217
ENST00000573008
I3L369 [Direct mapping]
Coilin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 37 aa
4.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.