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COIL

GENERAL INFORMATION

Gene name

 COIL

Gene description

 Coilin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression, most abundant in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
CAB069400
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and colorectal cancer (favourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB069400

GENE INFORMATION

Gene name

 COIL (HGNC Symbol)

Synonyms

 CLN80, p80-coilin

Description

 Coilin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q22

Chromosome location (bp)

 56938187 - 56961054

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121058 (version 83.38)

Entrez gene

 8161

UniProt

 P38432 (UniProt - Evidence at protein level)

neXtProt

 NX_P38432

Antibodypedia

 COIL antibodies

PROTEIN BROWSER
COIL-001
COIL-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COIL-001
ENSP00000240316
ENST00000240316
P38432 [Direct mapping]
Coilin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001674 [female germ cell nucleus]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0008022 [protein C-terminus binding]
GO:0015030 [Cajal body]
GO:0015036 [disulfide oxidoreductase activity]
GO:0016020 [membrane]
GO:0042802 [identical protein binding]
GO:0055114 [oxidation-reduction process]
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 576 aa
62.6 kDa 		No 0
COIL-002
ENSP00000460217
ENST00000573008
I3L369 [Direct mapping]
Coilin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 37 aa
4.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.