Expression of CSTA in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CSTA
Gene description	Cystatin A (stefin A)
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (hTCEpi, THP-1, U-698)
HPA (normal tissue):	Group enriched (esophagus, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic and nuclear expression in squamous epithelia, lymphoid cells and a few types of glandular epithelium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA001031 , CAB000469 , CAB047315
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA001031	CAB000469	CAB047315

GENE INFORMATION
Gene name	CSTA (HGNC Symbol)
Synonyms	STF1, STFA
Description	Cystatin A (stefin A) (HGNC Symbol)
Entrez gene summary	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q21.1
Chromosome location (bp)	122325244 - 122341972
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121552 (version 83.38)
Entrez gene	1475
UniProt	P01040 (UniProt - Evidence at protein level)
neXtProt	NX_P01040
Antibodypedia	CSTA antibodies

PROTEIN BROWSER

CSTA-001	CSTA-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSTA-001 ENSP00000264474 ENST00000264474	P01040 [Direct mapping] Cystatin-A Cystatin-A, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001533 [cornified envelope] GO:0002020 [protease binding] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005198 [structural molecule activity] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0010466 [negative regulation of peptidase activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0016337 [single organismal cell-cell adhesion] GO:0018149 [peptide cross-linking] GO:0030216 [keratinocyte differentiation] GO:0030674 [protein binding, bridging] GO:0045861 [negative regulation of proteolysis] GO:0070062 [extracellular exosome] Show all	98 aa 11 kDa	No	0
CSTA-002 ENSP00000418891 ENST00000479204	C9J0E4 [Direct mapping] Cystatin-A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005622 [intracellular] GO:0010951 [negative regulation of endopeptidase activity] Show all	63 aa 7.1 kDa	No	0