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CSTA

GENERAL INFORMATION

Gene name

 CSTA

Gene description

 Cystatin A (stefin A)

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, tonsil)
GTEx:Tissue enhanced (esophagus, vagina)
FANTOM5:Group enriched (cervix, uterine, esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic and nuclear expression in squamous epithelia, lymphoid cells and a few types of glandular epithelium.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA001031 , CAB000469 , CAB047315
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, esophagus, tonsil)

GENE INFORMATION

Gene name

 CSTA (HGNC Symbol)

Synonyms

 STF1, STFA

Description

 Cystatin A (stefin A) (HGNC Symbol)

Entrez gene summary

 The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q21.1

Chromosome location (bp)

 122325244 - 122341972

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121552 (version 83.38)

Entrez gene

 1475

UniProt

 P01040 (UniProt - Evidence at protein level)

neXtProt

 NX_P01040

Antibodypedia

 CSTA antibodies

PROTEIN BROWSER
CSTA-001
CSTA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSTA-001
ENSP00000264474
ENST00000264474
P01040 [Direct mapping]
Cystatin-A Cystatin-A, N-terminally processed
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001533 [cornified envelope]
GO:0002020 [protease binding]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005198 [structural molecule activity]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0010466 [negative regulation of peptidase activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018149 [peptide cross-linking]
GO:0030216 [keratinocyte differentiation]
GO:0030674 [protein binding, bridging]
GO:0045861 [negative regulation of proteolysis]
GO:0070062 [extracellular exosome]
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 98 aa
11 kDa 		No 0
CSTA-002
ENSP00000418891
ENST00000479204
C9J0E4 [Direct mapping]
Cystatin-A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005622 [intracellular]
GO:0010951 [negative regulation of endopeptidase activity]
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 63 aa
7.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.