Cell atlas - CBX3 - The Human Protein Atlas

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CBX3

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CBX3
Gene description	Chromobox homolog 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Additional location	In addition localized to the Nuclear bodies (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA004902
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nuclear bodies.

Main location

Nucleus (supported)

Additional location

Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA004902	A-431	Nucleus
	HPA004902	U-2 OS	Nucleus
	HPA004902	U-2 OS	Nuclear bodies
	HPA004902	U-251 MG	Nucleoplasm
	HPA004902	U-251 MG	Nuclear bodies

GENE INFORMATION
Gene name	CBX3 (HGNC Symbol)
Synonyms	HP1Hs-gamma
Description	Chromobox homolog 3 (HGNC Symbol)
Entrez gene summary	At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
Chromosome	7
Cytoband	p15.2
Chromosome location (bp)	26201162 - 26213356
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122565 (version 83.38)
Entrez gene	11335
UniProt	Q13185 (UniProt - Evidence at protein level)
neXtProt	NX_Q13185
Antibodypedia	CBX3 antibodies

PROTEIN BROWSER

CBX3-001	CBX3-002	CBX3-003	CBX3-004	CBX3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CBX3-001 ENSP00000336687 ENST00000337620	Q13185 [Direct mapping] Chromobox protein homolog 3 A4D177 [Target identity:100%; Query identity:100%] Chromobox homolog 3 (HP1 gamma homolog, Drosophila); Chromobox homolog 3 (HP1 gamma homolog, Drosophila), isoform CRA_a; Coiled-coil domain containing 32, isoform CRA_c Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0000779 [condensed chromosome, centromeric region] GO:0000784 [nuclear chromosome, telomeric region] GO:0000785 [chromatin] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0005719 [nuclear euchromatin] GO:0005720 [nuclear heterochromatin] GO:0005819 [spindle] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0010369 [chromocenter] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0031618 [nuclear pericentric heterochromatin] GO:0035985 [senescence-associated heterochromatin focus] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048511 [rhythmic process] GO:0071549 [cellular response to dexamethasone stimulus] GO:1990226 [histone methyltransferase binding] Show all	183 aa 20.8 kDa	No	0
CBX3-002 ENSP00000379670 ENST00000396386	Q13185 [Direct mapping] Chromobox protein homolog 3 A4D177 [Target identity:100%; Query identity:100%] Chromobox homolog 3 (HP1 gamma homolog, Drosophila); Chromobox homolog 3 (HP1 gamma homolog, Drosophila), isoform CRA_a; Coiled-coil domain containing 32, isoform CRA_c Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0000779 [condensed chromosome, centromeric region] GO:0000784 [nuclear chromosome, telomeric region] GO:0000785 [chromatin] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0005719 [nuclear euchromatin] GO:0005720 [nuclear heterochromatin] GO:0005819 [spindle] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0031618 [nuclear pericentric heterochromatin] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048511 [rhythmic process] GO:1990226 [histone methyltransferase binding] Show all	183 aa 20.8 kDa	No	0
CBX3-003 ENSP00000387348 ENST00000409747	B8ZZ43 [Direct mapping] Chromobox homolog 3 (HP1 gamma homolog, Drosophila), isoform CRA_b; Chromobox protein homolog 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	101 aa 11.9 kDa	No	0
CBX3-004 ENSP00000408672 ENST00000456948	C9JMM0 [Direct mapping] Chromobox protein homolog 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	62 aa 7.2 kDa	No	0
CBX3-006 ENSP00000473748 ENST00000462165	S4R2Y4 [Direct mapping] Chromobox protein homolog 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	107 aa 12.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.