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CBX3

GENERAL INFORMATION

Gene name

 CBX3

Gene description

 Chromobox homolog 3

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA004902 , CAB001973
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable), pancreatic cancer (unfavourable) and breast cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Pancreatic cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004902
CAB001973

GENE INFORMATION

Gene name

 CBX3 (HGNC Symbol)

Synonyms

 HP1Hs-gamma

Description

 Chromobox homolog 3 (HGNC Symbol)

Entrez gene summary

 At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]

Chromosome

 7

Cytoband

 p15.2

Chromosome location (bp)

 26201162 - 26213356

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122565 (version 83.38)

Entrez gene

 11335

UniProt

 Q13185 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13185

Antibodypedia

 CBX3 antibodies

PROTEIN BROWSER
CBX3-001
CBX3-002
CBX3-003
CBX3-004
CBX3-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CBX3-001
ENSP00000336687
ENST00000337620
Q13185 [Direct mapping]
Chromobox protein homolog 3
A4D177 [Target identity:100%; Query identity:100%]
Chromobox homolog 3 (HP1 gamma homolog, Drosophila); Chromobox homolog 3 (HP1 gamma homolog, Drosophila), isoform CRA_a; Coiled-coil domain containing 32, isoform CRA_c
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000775 [chromosome, centromeric region]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005719 [nuclear euchromatin]
GO:0005720 [nuclear heterochromatin]
GO:0005819 [spindle]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0010369 [chromocenter]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0031618 [nuclear pericentric heterochromatin]
GO:0035985 [senescence-associated heterochromatin focus]
GO:0042802 [identical protein binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:1990226 [histone methyltransferase binding]
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 183 aa
20.8 kDa 		No 0
CBX3-002
ENSP00000379670
ENST00000396386
Q13185 [Direct mapping]
Chromobox protein homolog 3
A4D177 [Target identity:100%; Query identity:100%]
Chromobox homolog 3 (HP1 gamma homolog, Drosophila); Chromobox homolog 3 (HP1 gamma homolog, Drosophila), isoform CRA_a; Coiled-coil domain containing 32, isoform CRA_c
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005719 [nuclear euchromatin]
GO:0005720 [nuclear heterochromatin]
GO:0005819 [spindle]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0031618 [nuclear pericentric heterochromatin]
GO:0042802 [identical protein binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
GO:1990226 [histone methyltransferase binding]
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 183 aa
20.8 kDa 		No 0
CBX3-003
ENSP00000387348
ENST00000409747
B8ZZ43 [Direct mapping]
Chromobox homolog 3 (HP1 gamma homolog, Drosophila), isoform CRA_b; Chromobox protein homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 101 aa
11.9 kDa 		No 0
CBX3-004
ENSP00000408672
ENST00000456948
C9JMM0 [Direct mapping]
Chromobox protein homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 62 aa
7.2 kDa 		No 0
CBX3-006
ENSP00000473748
ENST00000462165
S4R2Y4 [Direct mapping]
Chromobox protein homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 107 aa
12.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.