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EXOSC9

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GENERAL INFORMATION

Gene name

 EXOSC9

Gene description

 Exosome component 9

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoli. In addition localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (validated)

Additional location

 In addition localized to the Nucleus (supported)

GFP

 The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA041838
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ASSAYS
RNA expression
Human cells
GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoli. In addition localized to the nucleus.

Main location

 Nucleoli (validated)

Additional location

 Nucleus (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA041838 A-431 Nucleoli
HPA041838 U-251 MG Nucleoli

GFP

Antibody

 HPA041838

Validation

C-terminal tag
BAC cell line: 5902
Validated: Antibody staining overlaps with GFP tagged protein

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

BAC id

Tag

Location antibody staining

Location tagged protein
HPA041838 HeLa 5902 C-terminal Nucleus, Nucleoli Nucleus, Nucleoli
HPA041838 HeLa Normal - Nucleus, Nucleoli, Cytosol -

GENE INFORMATION

Gene name

 EXOSC9 (HGNC Symbol)

Synonyms

 p5, p6, PM/Scl-75, PMSCL1, RRP45, Rrp45p

Description

 Exosome component 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Chromosome

 4

Cytoband

 q27

Chromosome location (bp)

 121801317 - 121817021

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123737 (version 83.38)

Entrez gene

 5393

UniProt

 Q06265 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06265

Antibodypedia

 EXOSC9 antibodies

PROTEIN BROWSER
EXOSC9-001
EXOSC9-003
EXOSC9-005
EXOSC9-008
EXOSC9-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXOSC9-001
ENSP00000243498
ENST00000243498
Q06265 [Direct mapping]
Exosome complex component RRP45
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000228 [nuclear chromosome]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0006955 [immune response]
GO:0010467 [gene expression]
GO:0017091 [AU-rich element binding]
GO:0030307 [positive regulation of cell growth]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034473 [U1 snRNA 3'-end processing]
GO:0034475 [U4 snRNA 3'-end processing]
GO:0034476 [U5 snRNA 3'-end processing]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0070062 [extracellular exosome]
GO:0071028 [nuclear mRNA surveillance]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process]
GO:0071042 [nuclear polyadenylation-dependent mRNA catabolic process]
Show all
 439 aa
48.9 kDa 		No 0
EXOSC9-003
ENSP00000368984
ENST00000379663
Q06265 [Direct mapping]
Exosome complex component RRP45
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000228 [nuclear chromosome]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0006955 [immune response]
GO:0010467 [gene expression]
GO:0017091 [AU-rich element binding]
GO:0030307 [positive regulation of cell growth]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034473 [U1 snRNA 3'-end processing]
GO:0034475 [U4 snRNA 3'-end processing]
GO:0034476 [U5 snRNA 3'-end processing]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0070062 [extracellular exosome]
GO:0071028 [nuclear mRNA surveillance]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process]
GO:0071042 [nuclear polyadenylation-dependent mRNA catabolic process]
Show all
 456 aa
50.8 kDa 		No 0
EXOSC9-005
ENSP00000425782
ENST00000512454
D6RIY6 [Direct mapping]
Exosome complex component RRP45; Exosome component 9, isoform CRA_f
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 423 aa
47 kDa 		No 0
EXOSC9-008
ENSP00000422205
ENST00000509800
D6R905 [Direct mapping]
Exosome complex component RRP45
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 226 aa
25.7 kDa 		No 0
EXOSC9-011
ENSP00000424504
ENST00000511132
H0Y9L5 [Direct mapping]
Exosome complex component RRP45
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 172 aa
18.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.