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EXOSC9

GENERAL INFORMATION

Gene name

 EXOSC9

Gene description

 Exosome component 9

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA041838 , HPA048257 , CAB070171
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041838
HPA048257
CAB070171

GENE INFORMATION

Gene name

 EXOSC9 (HGNC Symbol)

Synonyms

 p5, p6, PM/Scl-75, PMSCL1, RRP45, Rrp45p

Description

 Exosome component 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Chromosome

 4

Cytoband

 q27

Chromosome location (bp)

 121801317 - 121817021

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123737 (version 83.38)

Entrez gene

 5393

UniProt

 Q06265 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06265

Antibodypedia

 EXOSC9 antibodies

PROTEIN BROWSER
EXOSC9-001
EXOSC9-003
EXOSC9-005
EXOSC9-008
EXOSC9-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXOSC9-001
ENSP00000243498
ENST00000243498
Q06265 [Direct mapping]
Exosome complex component RRP45
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000228 [nuclear chromosome]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0006955 [immune response]
GO:0010467 [gene expression]
GO:0017091 [AU-rich element binding]
GO:0030307 [positive regulation of cell growth]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034473 [U1 snRNA 3'-end processing]
GO:0034475 [U4 snRNA 3'-end processing]
GO:0034476 [U5 snRNA 3'-end processing]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0070062 [extracellular exosome]
GO:0071028 [nuclear mRNA surveillance]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process]
GO:0071042 [nuclear polyadenylation-dependent mRNA catabolic process]
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 439 aa
48.9 kDa 		No 0
EXOSC9-003
ENSP00000368984
ENST00000379663
Q06265 [Direct mapping]
Exosome complex component RRP45
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000228 [nuclear chromosome]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0006955 [immune response]
GO:0010467 [gene expression]
GO:0017091 [AU-rich element binding]
GO:0030307 [positive regulation of cell growth]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034473 [U1 snRNA 3'-end processing]
GO:0034475 [U4 snRNA 3'-end processing]
GO:0034476 [U5 snRNA 3'-end processing]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0070062 [extracellular exosome]
GO:0071028 [nuclear mRNA surveillance]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process]
GO:0071042 [nuclear polyadenylation-dependent mRNA catabolic process]
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 456 aa
50.8 kDa 		No 0
EXOSC9-005
ENSP00000425782
ENST00000512454
D6RIY6 [Direct mapping]
Exosome complex component RRP45; Exosome component 9, isoform CRA_f
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0045111 [intermediate filament cytoskeleton]
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 423 aa
47 kDa 		No 0
EXOSC9-008
ENSP00000422205
ENST00000509800
D6R905 [Direct mapping]
Exosome complex component RRP45
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 226 aa
25.7 kDa 		No 0
EXOSC9-011
ENSP00000424504
ENST00000511132
H0Y9L5 [Direct mapping]
Exosome complex component RRP45
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 172 aa
18.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.