Cell atlas - PRICKLE4 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PRICKLE4
Gene description	Prickle homolog 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubule organizing center. In addition localized to the mitotic spindle. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (AF22, TIME, HeLa, ASC TERT1)
Protein evidence	Evidence at transcript level
Main location	Localized to the Microtubule organizing center (uncertain)
Additional location	In addition localized to the Mitotic spindle (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA031240
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, TIME, HeLa, ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubule organizing center. In addition localized to the mitotic spindle. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Microtubule organizing center (uncertain)

Additional location

Mitotic spindle (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031240	HaCaT	Microtubule organizing center
	HPA031240	HeLa	Mitotic spindle	Intensity	Intensity

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Mitotic spindle

GENE INFORMATION
Gene name	PRICKLE4 (HGNC Symbol)
Synonyms	C6orf49, DKFZp761H221, OEBT
Description	Prickle homolog 4 (HGNC Symbol)
Entrez gene summary	C6ORF49 is a member of the LIM domain protein family (Teufel et al., 2005 [PubMed 15702247]).[supplied by OMIM, Mar 2008]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	41780349 - 41790141
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000124593 (version 83.38)
Entrez gene	29964
UniProt	Q2TBC4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q2TBC4
Antibodypedia	PRICKLE4 antibodies

PROTEIN BROWSER

PRICKLE4-201	PRICKLE4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRICKLE4-201 ENSP00000352128 ENST00000359201	Q2TBC4 [Direct mapping] Prickle-like protein 4 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0008150 [biological_process] GO:0008270 [zinc ion binding] Show all	344 aa 37.6 kDa	No	0
PRICKLE4-202 ENSP00000404911 ENST00000458694	Q2TBC4 [Direct mapping] Prickle-like protein 4 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0008150 [biological_process] GO:0008270 [zinc ion binding] Show all	384 aa 41.8 kDa	No	0