Expression of RIOK1 in cancer - Summary

GENERAL INFORMATION
Gene name	RIOK1
Gene description	RIO kinase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues. High expression in spermatogonia in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Paired antibodies with high similarity supports the protein expression profile.
Reliability score	Supported based on 2 antibodies. HPA017866 , HPA051446
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and melanoma (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA017866	HPA051446

GENE INFORMATION
Gene name	RIOK1 (HGNC Symbol)
Synonyms	AD034, bA288G3.1, FLJ30006, RRP10
Description	RIO kinase 1 (HGNC Symbol)
Entrez gene summary	This gene includes two alternatively spliced transcript variants, which encode different isoforms. The function of this gene has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p24.3
Chromosome location (bp)	7389496 - 7418037
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124784 (version 83.38)
Entrez gene	83732
UniProt	Q9BRS2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BRS2
Antibodypedia	RIOK1 antibodies

PROTEIN BROWSER

RIOK1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RIOK1-001 ENSP00000369162 ENST00000379834	Q9BRS2 [Direct mapping] Serine/threonine-protein kinase RIO1 Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	568 aa 65.6 kDa	No	0