Cell atlas - INSIG2 - The Human Protein Atlas

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INSIG2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	INSIG2
Gene description	Insulin induced gene 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	INSIG2
Synonyms
Description	Insulin induced gene 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband
Chromosome location (bp)	118088452 - 118110997
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125629 (version 83.38)
Entrez gene	51141
UniProt	Q9Y5U4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5U4
Antibodypedia	INSIG2 antibodies

PROTEIN BROWSER

INSIG2-001	INSIG2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INSIG2-001 ENSP00000245787 ENST00000245787	Q9Y5U4 [Direct mapping] Insulin-induced gene 2 protein A0A024RAI2 [Target identity:100%; Query identity:100%] Insulin-induced gene protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006641 [triglyceride metabolic process] GO:0006695 [cholesterol biosynthetic process] GO:0006991 [response to sterol depletion] GO:0008134 [transcription factor binding] GO:0008203 [cholesterol metabolic process] GO:0010894 [negative regulation of steroid biosynthetic process] GO:0016126 [sterol biosynthetic process] GO:0032868 [response to insulin] GO:0032933 [SREBP signaling pathway] GO:0032937 [SREBP-SCAP-Insig complex] GO:0033993 [response to lipid] GO:0042472 [inner ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0044281 [small molecule metabolic process] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0060021 [palate development] GO:0060363 [cranial suture morphogenesis] GO:0070542 [response to fatty acid] Show all	225 aa 24.8 kDa	No	6
INSIG2-201 ENSP00000484179 ENST00000614681	A0A0C4DGZ4 [Direct mapping] Insulin-induced gene protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0008203 [cholesterol metabolic process] GO:0016021 [integral component of membrane] Show all	238 aa 26.4 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.