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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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INSIG2
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

INSIG2

Gene description

Insulin induced gene 2

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
CAB033861
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in pancreatic cancer (unfavourable), renal cancer (unfavourable) and head and neck cancer (unfavourable).
Pancreatic cancer p<0.001
Renal cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB033861

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer cells displayed moderate cytoplasmic positivity. A few cases of colorectal and thyroid cancers were strongly stained. Several cases of lymphomas were weakly stained or negative.

GENE INFORMATION

Gene name

INSIG2

Synonyms

Description

Insulin induced gene 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

Chromosome location (bp)

118088452 - 118110997

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125629 (version 83.38)

Entrez gene

51141

UniProt

Q9Y5U4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5U4

Antibodypedia

INSIG2 antibodies

PROTEIN BROWSER

INSIG2-001
INSIG2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INSIG2-001
ENSP00000245787
ENST00000245787
Q9Y5U4 [Direct mapping]
Insulin-induced gene 2 protein
A0A024RAI2 [Target identity:100%; Query identity:100%]
Insulin-induced gene protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006641 [triglyceride metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006991 [response to sterol depletion]
GO:0008134 [transcription factor binding]
GO:0008203 [cholesterol metabolic process]
GO:0010894 [negative regulation of steroid biosynthetic process]
GO:0016126 [sterol biosynthetic process]
GO:0032868 [response to insulin]
GO:0032933 [SREBP signaling pathway]
GO:0032937 [SREBP-SCAP-Insig complex]
GO:0033993 [response to lipid]
GO:0042472 [inner ear morphogenesis]
GO:0042474 [middle ear morphogenesis]
GO:0044281 [small molecule metabolic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0060021 [palate development]
GO:0060363 [cranial suture morphogenesis]
GO:0070542 [response to fatty acid]
Show all
225 aa
24.8 kDa
No 6
INSIG2-201
ENSP00000484179
ENST00000614681
A0A0C4DGZ4 [Direct mapping]
Insulin-induced gene protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0008203 [cholesterol metabolic process]
GO:0016021 [integral component of membrane]
Show all
238 aa
26.4 kDa
No 6

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