We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
A majority of cancer cells displayed moderate cytoplasmic positivity. A few cases of colorectal and thyroid cancers were strongly stained. Several cases of lymphomas were weakly stained or negative.
GENE INFORMATION
Gene name
INSIG2
Synonyms
Description
Insulin induced gene 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]