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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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INSIG2
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

INSIG2

Gene description

Insulin induced gene 2

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in all tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
CAB033861
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

INSIG2

Synonyms

Description

Insulin induced gene 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

Chromosome location (bp)

118088452 - 118110997

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125629 (version 83.38)

Entrez gene

51141

UniProt

Q9Y5U4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5U4

Antibodypedia

INSIG2 antibodies

PROTEIN BROWSER

INSIG2-001
INSIG2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INSIG2-001
ENSP00000245787
ENST00000245787
Q9Y5U4 [Direct mapping]
Insulin-induced gene 2 protein
A0A024RAI2 [Target identity:100%; Query identity:100%]
Insulin-induced gene protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006641 [triglyceride metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006991 [response to sterol depletion]
GO:0008134 [transcription factor binding]
GO:0008203 [cholesterol metabolic process]
GO:0010894 [negative regulation of steroid biosynthetic process]
GO:0016126 [sterol biosynthetic process]
GO:0032868 [response to insulin]
GO:0032933 [SREBP signaling pathway]
GO:0032937 [SREBP-SCAP-Insig complex]
GO:0033993 [response to lipid]
GO:0042472 [inner ear morphogenesis]
GO:0042474 [middle ear morphogenesis]
GO:0044281 [small molecule metabolic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0060021 [palate development]
GO:0060363 [cranial suture morphogenesis]
GO:0070542 [response to fatty acid]
Show all
225 aa
24.8 kDa
No 6
INSIG2-201
ENSP00000484179
ENST00000614681
A0A0C4DGZ4 [Direct mapping]
Insulin-induced gene protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0008203 [cholesterol metabolic process]
GO:0016021 [integral component of membrane]
Show all
238 aa
26.4 kDa
No 6

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