Expression of STK35 in cancer - Summary - The Human Protein Atlas

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STK35

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	STK35
Gene description	Serine/threonine kinase 35
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA051673
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051673

GENE INFORMATION
Gene name	STK35 (HGNC Symbol)
Synonyms	bA550O8.2, CLIK1
Description	Serine/threonine kinase 35 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	2101611 - 2177038
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125834 (version 83.38)
Entrez gene	140901
UniProt	Q8TDR2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDR2
Antibodypedia	STK35 antibodies

PROTEIN BROWSER

STK35-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STK35-001 ENSP00000370891 ENST00000381482	Q8TDR2 [Direct mapping] Serine/threonine-protein kinase 35 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	534 aa 58.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.