Cell atlas - FFAR1 - The Human Protein Atlas

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FFAR1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	FFAR1
Gene description	Free fatty acid receptor 1
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (U-698)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-698) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	FFAR1 (HGNC Symbol)
Synonyms	FFA1R, GPR40
Description	Free fatty acid receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35351552 - 35353862
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126266 (version 83.38)
Entrez gene	2864
UniProt	O14842 (UniProt - Evidence at protein level)
neXtProt	NX_O14842
Antibodypedia	FFAR1 antibodies

PROTEIN BROWSER

FFAR1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FFAR1-001 ENSP00000246553 ENST00000246553	O14842 [Direct mapping] Free fatty acid receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] GO:0030073 [insulin secretion] GO:0032024 [positive regulation of insulin secretion] GO:0042593 [glucose homeostasis] GO:0043547 [positive regulation of GTPase activity] GO:0044281 [small molecule metabolic process] GO:0045125 [bioactive lipid receptor activity] GO:0050796 [regulation of insulin secretion] GO:0051928 [positive regulation of calcium ion transport] GO:0070542 [response to fatty acid] Show all	300 aa 31.5 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.