Tissue expression of FFAR1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FFAR1
Gene description	Free fatty acid receptor 1
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (bone marrow)
GTEx:	Tissue enhanced (ovary, pancreas)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (bone marrow)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (ovary, pancreas)

GENE INFORMATION
Gene name	FFAR1 (HGNC Symbol)
Synonyms	FFA1R, GPR40
Description	Free fatty acid receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35351552 - 35353862
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126266 (version 83.38)
Entrez gene	2864
UniProt	O14842 (UniProt - Evidence at protein level)
neXtProt	NX_O14842
Antibodypedia	FFAR1 antibodies

PROTEIN BROWSER

FFAR1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FFAR1-001 ENSP00000246553 ENST00000246553	O14842 [Direct mapping] Free fatty acid receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] GO:0030073 [insulin secretion] GO:0032024 [positive regulation of insulin secretion] GO:0042593 [glucose homeostasis] GO:0043547 [positive regulation of GTPase activity] GO:0044281 [small molecule metabolic process] GO:0045125 [bioactive lipid receptor activity] GO:0050796 [regulation of insulin secretion] GO:0051928 [positive regulation of calcium ion transport] GO:0070542 [response to fatty acid] Show all	300 aa 31.5 kDa	No	7