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FFAR1

GENERAL INFORMATION

Gene name

 FFAR1

Gene description

 Free fatty acid receptor 1

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (pancreatic cancer)
HPA (cell line):Cell line enhanced (U-698)
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 FFAR1 (HGNC Symbol)

Synonyms

 FFA1R, GPR40

Description

 Free fatty acid receptor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]

Chromosome

 19

Cytoband

 q13.12

Chromosome location (bp)

 35351552 - 35353862

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126266 (version 83.38)

Entrez gene

 2864

UniProt

 O14842 (UniProt - Evidence at protein level)

neXtProt

 NX_O14842

Antibodypedia

 FFAR1 antibodies

PROTEIN BROWSER
FFAR1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FFAR1-001
ENSP00000246553
ENST00000246553
O14842 [Direct mapping]
Free fatty acid receptor 1
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0004930 [G-protein coupled receptor activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008289 [lipid binding]
GO:0016021 [integral component of membrane]
GO:0030073 [insulin secretion]
GO:0032024 [positive regulation of insulin secretion]
GO:0042593 [glucose homeostasis]
GO:0043547 [positive regulation of GTPase activity]
GO:0044281 [small molecule metabolic process]
GO:0045125 [bioactive lipid receptor activity]
GO:0050796 [regulation of insulin secretion]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070542 [response to fatty acid]
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 300 aa
31.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.