Expression of CSN1S1 in cancer - Summary

GENERAL INFORMATION
Gene name	CSN1S1
Gene description	Casein alpha s1
Protein class	Cancer-related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (breast cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (breast)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression with additional plasma positivity in lactating breast.

ANTIBODY IHC RELIABILITY
Data reliability description	No internal RNA expression data available for correlation. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA035659 , HPA057031
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA035659	HPA057031

GENE INFORMATION
Gene name	CSN1S1 (HGNC Symbol)
Synonyms	CASA, CSN1
Description	Casein alpha s1 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	69931081 - 69946574
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126545 (version 83.38)
Entrez gene	1446
UniProt	P47710 (UniProt - Evidence at protein level)
neXtProt	NX_P47710
Antibodypedia	CSN1S1 antibodies

PROTEIN BROWSER

CSN1S1-001	CSN1S1-002	CSN1S1-003	CSN1S1-004	CSN1S1-005	CSN1S1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSN1S1-001 ENSP00000246891 ENST00000246891	P47710 [Direct mapping] Alpha-S1-casein Casoxin-D Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005215 [transporter activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0055085 [transmembrane transport] Show all	185 aa 21.7 kDa	Yes	0
CSN1S1-002 ENSP00000427490 ENST00000507772	E9PDQ1 [Direct mapping] Alpha-S1-casein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005215 [transporter activity] GO:0005576 [extracellular region] GO:0006810 [transport] Show all	177 aa 20.8 kDa	Yes	0
CSN1S1-003 ENSP00000422611 ENST00000507763	P47710 [Direct mapping] Alpha-S1-casein Casoxin-D Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005215 [transporter activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0055085 [transmembrane transport] Show all	176 aa 20.7 kDa	Yes	0
CSN1S1-004 ENSP00000421314 ENST00000510936	H0Y8K1 [Direct mapping] Alpha-S1-casein Show all	Predicted intracellular proteins Show all	GO:0005215 [transporter activity] GO:0005576 [extracellular region] GO:0006810 [transport] Show all	76 aa 9 kDa	No	0
CSN1S1-005 ENSP00000426684 ENST00000505782	D6RF34 [Direct mapping] Alpha-S1-casein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005215 [transporter activity] GO:0005576 [extracellular region] GO:0006810 [transport] Show all	169 aa 19.9 kDa	Yes	0
CSN1S1-006 ENSP00000487633 ENST00000633258		Predicted intracellular proteins Show all		55 aa 6.4 kDa	No	0