Cell atlas - TRAP1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TRAP1
Gene description	TNF receptor-associated protein 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.
Mouse	Localized to the Mitochondria in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA041082 , HPA044227
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria.

Main location

Mitochondria (validated)


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Antibody	Cell line	Location
HPA041082	A-431	Nucleoplasm
HPA041082	A-431	Mitochondria
HPA041082	MCF7	Mitochondria
HPA041082	U-2 OS	Mitochondria
HPA044227	A-431	Mitochondria
HPA044227	MCF7	Mitochondria
HPA044227	U-2 OS	Mitochondria

siRNA VALIDATION

Antibody

HPA044227

siRNA validation

Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

Cytoplasmic region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

31%

39%

p-value

< 0.01


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Antibody	Sample	Cell line
HPA044227	siRNA 1	U-2 OS
HPA044227	siRNA 2	U-2 OS
HPA044227	scrambled	U-2 OS

MOUSE CELLS

Main location

Mitochondria

Additional location

Nucleus

Mouse gene

ENSMUSG00000005981 (version 83)


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Thumbnail	Antibody	Cell line	Location
	HPA041082	NIH 3T3	Nucleus
	HPA041082	NIH 3T3	Mitochondria

GENE INFORMATION
Gene name	TRAP1 (HGNC Symbol)
Synonyms	HSP75, HSP90L
Description	TNF receptor-associated protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	3651639 - 3717597
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126602 (version 83.38)
Entrez gene	10131
UniProt	Q12931 (UniProt - Evidence at protein level)
neXtProt	NX_Q12931
Antibodypedia	TRAP1 antibodies

PROTEIN BROWSER

TRAP1-001	TRAP1-003	TRAP1-004	TRAP1-010	TRAP1-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRAP1-001 ENSP00000246957 ENST00000246957	Q12931 [Direct mapping] Heat shock protein 75 kDa, mitochondrial Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005758 [mitochondrial intermembrane space] GO:0005759 [mitochondrial matrix] GO:0005811 [lipid particle] GO:0006457 [protein folding] GO:0006950 [response to stress] GO:0009386 [translational attenuation] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0044822 [poly(A) RNA binding] GO:0051082 [unfolded protein binding] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular exosome] GO:1901856 [negative regulation of cellular respiration] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] Show all	704 aa 80.1 kDa	No	0
TRAP1-003 ENSP00000442070 ENST00000538171	Q12931 [Direct mapping] Heat shock protein 75 kDa, mitochondrial Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005758 [mitochondrial intermembrane space] GO:0005759 [mitochondrial matrix] GO:0005811 [lipid particle] GO:0006457 [protein folding] GO:0006950 [response to stress] GO:0009386 [translational attenuation] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0044822 [poly(A) RNA binding] GO:0051082 [unfolded protein binding] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular exosome] GO:1901856 [negative regulation of cellular respiration] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] Show all	651 aa 74.3 kDa	No	0
TRAP1-004 ENSP00000458166 ENST00000575671	I3L0K7 [Direct mapping] Heat shock protein 75 kDa, mitochondrial; TNF receptor-associated protein 1, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006457 [protein folding] GO:0006950 [response to stress] GO:0051082 [unfolded protein binding] Show all	495 aa 57.2 kDa	No	0
TRAP1-010 ENSP00000458244 ENST00000571538	I3L0P6 [Direct mapping] Heat shock protein 75 kDa, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0006457 [protein folding] GO:0006950 [response to stress] GO:0051082 [unfolded protein binding] Show all	36 aa 3.9 kDa	No	0
TRAP1-018 ENSP00000459354 ENST00000576335	I3L239 [Direct mapping] Heat shock protein 75 kDa, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0006457 [protein folding] GO:0006950 [response to stress] GO:0051082 [unfolded protein binding] Show all	215 aa 24.9 kDa	No	0