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TRAP1

GENERAL INFORMATION

Gene name

 TRAP1

Gene description

 TNF receptor-associated protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041082 , HPA044227
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041082
HPA044227

GENE INFORMATION

Gene name

 TRAP1 (HGNC Symbol)

Synonyms

 HSP75, HSP90L

Description

 TNF receptor-associated protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 3651639 - 3717597

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126602 (version 83.38)

Entrez gene

 10131

UniProt

 Q12931 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12931

Antibodypedia

 TRAP1 antibodies

PROTEIN BROWSER
TRAP1-001
TRAP1-003
TRAP1-004
TRAP1-010
TRAP1-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRAP1-001
ENSP00000246957
ENST00000246957
Q12931 [Direct mapping]
Heat shock protein 75 kDa, mitochondrial
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005811 [lipid particle]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0009386 [translational attenuation]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0044822 [poly(A) RNA binding]
GO:0051082 [unfolded protein binding]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
GO:1901856 [negative regulation of cellular respiration]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903427 [negative regulation of reactive oxygen species biosynthetic process]
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 704 aa
80.1 kDa 		No 0
TRAP1-003
ENSP00000442070
ENST00000538171
Q12931 [Direct mapping]
Heat shock protein 75 kDa, mitochondrial
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005811 [lipid particle]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0009386 [translational attenuation]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0044822 [poly(A) RNA binding]
GO:0051082 [unfolded protein binding]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
GO:1901856 [negative regulation of cellular respiration]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903427 [negative regulation of reactive oxygen species biosynthetic process]
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 651 aa
74.3 kDa 		No 0
TRAP1-004
ENSP00000458166
ENST00000575671
I3L0K7 [Direct mapping]
Heat shock protein 75 kDa, mitochondrial; TNF receptor-associated protein 1, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]
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 495 aa
57.2 kDa 		No 0
TRAP1-010
ENSP00000458244
ENST00000571538
I3L0P6 [Direct mapping]
Heat shock protein 75 kDa, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]
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 36 aa
3.9 kDa 		No 0
TRAP1-018
ENSP00000459354
ENST00000576335
I3L239 [Direct mapping]
Heat shock protein 75 kDa, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]
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 215 aa
24.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.