Cell atlas - PLEKHG3 - The Human Protein Atlas

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PLEKHG3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Cytokinetic bridge
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Centrosome
	Cytosol
	Microtubules
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PLEKHG3
Gene description	Pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol. In addition localized to the cytokinetic bridge, centrosome & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported), Cytosol (supported)
Additional location	In addition localized to the Nucleoplasm (supported), Cytokinetic bridge (approved), Centrosome (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA063455 , HPA065323
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol. In addition localized to the cytokinetic bridge, centrosome & nucleoplasm.

Main location

Plasma membrane (supported), Cytosol (supported)

Additional location

Nucleoplasm (supported), Cytokinetic bridge (approved), Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA063455	A-431	Nucleoplasm
		Plasma membrane
		Cytosol
HPA063455	HaCaT	Plasma membrane
HPA063455	HaCaT	Cytosol
HPA063455	U-2 OS	Plasma membrane
HPA063455	U-2 OS	Cytosol
HPA065323	A-431	Nucleoplasm
		Plasma membrane
		Cytokinetic bridge	Intensity	Intensity
		Centrosome
HPA065323	HaCaT	Nucleoplasm
		Plasma membrane
		Cytokinetic bridge	Intensity	Intensity
		Centrosome
HPA065323	U-2 OS	Nucleus
HPA065323	U-2 OS	Centrosome

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	PLEKHG3 (HGNC Symbol)
Synonyms	ARHGEF43, KIAA0599
Description	Pleckstrin homology domain containing, family G (with RhoGef domain) member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q23.3
Chromosome location (bp)	64704102 - 64750247
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126822 (version 83.38)
Entrez gene	26030
UniProt	A1L390 (UniProt - Evidence at protein level)
neXtProt	NX_A1L390
Antibodypedia	PLEKHG3 antibodies

PROTEIN BROWSER

PLEKHG3-004	PLEKHG3-005	PLEKHG3-010	PLEKHG3-012	PLEKHG3-013	PLEKHG3-014	PLEKHG3-015	PLEKHG3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHG3-004 ENSP00000489373 ENST00000634379		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] Show all	603 aa 67.7 kDa	No	0
PLEKHG3-005 ENSP00000450945 ENST00000471182	A1L390 [Direct mapping] Pleckstrin homology domain-containing family G member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	752 aa 80.9 kDa	No	0
PLEKHG3-010 ENSP00000247226 ENST00000247226	A1L390 [Direct mapping] Pleckstrin homology domain-containing family G member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1219 aa 134.4 kDa	No	0
PLEKHG3-012 ENSP00000450973 ENST00000484731	G3V311 [Direct mapping] Pleckstrin homology domain-containing family G member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		724 aa 77.8 kDa	No	0
PLEKHG3-013 ENSP00000450501 ENST00000555982	G3V278 [Direct mapping] Pleckstrin homology domain-containing family G member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	188 aa 20.6 kDa	No	0
PLEKHG3-014 ENSP00000450880 ENST00000554088	G3V2V2 [Direct mapping] Pleckstrin homology domain-containing family G member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 6.4 kDa	No	0
PLEKHG3-015 ENSP00000451256 ENST00000554499	G3V3I3 [Direct mapping] Pleckstrin homology domain-containing family G member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	161 aa 17.4 kDa	No	0
PLEKHG3-201 ENSP00000378183 ENST00000394691	A1L390 [Direct mapping] Pleckstrin homology domain-containing family G member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1163 aa 128.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.