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CANX

GENERAL INFORMATION

Gene name

 CANX

Gene description

 Calnexin

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 13
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA009433 , HPA009696 , CAB004738
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CANX (HGNC Symbol)

Synonyms

 CNX, IP90, P90

Description

 Calnexin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.3

Chromosome location (bp)

 179678628 - 179730925

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127022 (version 83.38)

Entrez gene

 821

UniProt

 P27824 (UniProt - Evidence at protein level)

neXtProt

 NX_P27824

Antibodypedia

 CANX antibodies

PROTEIN BROWSER
«
CANX-001
CANX-002
CANX-003
CANX-005
CANX-006
CANX-007
CANX-008
CANX-009
CANX-010
CANX-014
CANX-017
CANX-018
CANX-021
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CANX-001
ENSP00000247461
ENST00000247461
P27824 [Direct mapping]
Calnexin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005840 [ribosome]
GO:0006457 [protein folding]
GO:0007568 [aging]
GO:0009306 [protein secretion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030246 [carbohydrate binding]
GO:0030424 [axon]
GO:0032839 [dendrite cytoplasm]
GO:0034185 [apolipoprotein binding]
GO:0034975 [protein folding in endoplasmic reticulum]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0042470 [melanosome]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043209 [myelin sheath]
GO:0043234 [protein complex]
GO:0043687 [post-translational protein modification]
GO:0044233 [ER-mitochondrion membrane contact site]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0048488 [synaptic vesicle endocytosis]
GO:0051082 [unfolded protein binding]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 592 aa
67.6 kDa 		Yes 1
CANX-002
ENSP00000424063
ENST00000504734
P27824 [Direct mapping]
Calnexin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0009306 [protein secretion]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030246 [carbohydrate binding]
GO:0034975 [protein folding in endoplasmic reticulum]
GO:0042470 [melanosome]
GO:0043687 [post-translational protein modification]
GO:0044233 [ER-mitochondrion membrane contact site]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0048488 [synaptic vesicle endocytosis]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 592 aa
67.6 kDa 		Yes 1
CANX-003
ENSP00000421107
ENST00000502673
D6RGY2 [Direct mapping]
Calnexin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 308 aa
35.2 kDa 		Yes 0
CANX-005
ENSP00000391646
ENST00000452673
P27824 [Direct mapping]
Calnexin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0009306 [protein secretion]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030246 [carbohydrate binding]
GO:0034975 [protein folding in endoplasmic reticulum]
GO:0042470 [melanosome]
GO:0043687 [post-translational protein modification]
GO:0044233 [ER-mitochondrion membrane contact site]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0048488 [synaptic vesicle endocytosis]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 592 aa
67.6 kDa 		Yes 1
CANX-006
ENSP00000424745
ENST00000502296
D6RAU8 [Direct mapping]
Calnexin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 134 aa
14.8 kDa 		Yes 0
CANX-007
ENSP00000425246
ENST00000502498
D6RDP7 [Direct mapping]
Calnexin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 168 aa
18.7 kDa 		Yes 0
CANX-008
ENSP00000426052
ENST00000507307
D6RHJ3 [Direct mapping]
Calnexin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 79 aa
8.6 kDa 		Yes 0
CANX-009
ENSP00000421813
ENST00000513246
D6RAQ8 [Direct mapping]
Calnexin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 107 aa
11.9 kDa 		Yes 0
CANX-010
ENSP00000421434
ENST00000509563
D6RFW4 [Direct mapping]
Calnexin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 32 aa
3.6 kDa 		Yes 0
CANX-014
ENSP00000424140
ENST00000508787
H0Y9H1 [Direct mapping]
Calnexin
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 190 aa
21.4 kDa 		No 0
CANX-017
ENSP00000426555
ENST00000506654
D6RFL1 [Direct mapping]
Calnexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 131 aa
15.2 kDa 		No 0
CANX-018
ENSP00000424740
ENST00000510810
H0Y9Q7 [Direct mapping]
Calnexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 170 aa
18.7 kDa 		No 0
CANX-021
ENSP00000424341
ENST00000514383
D6RB85 [Direct mapping]
Calnexin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 144 aa
16 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.