Cell atlas - ADGRE2 - The Human Protein Atlas

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ADGRE2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	ADGRE2
Gene description	Adhesion G protein-coupled receptor E2
Protein class	CD markers G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles.
RNA cell category	Cell line enhanced (HMC-1, U-937, HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA055200
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, U-937, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055200	HeLa	Vesicles
	HPA055200	HeLa	Cytosol
	HPA055200	U-2 OS	Vesicles
	HPA055200	U-2 OS	Cytosol
	HPA055200	U-251 MG	Vesicles
	HPA055200	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ADGRE2 (HGNC Symbol)
Synonyms	CD312, EMR2
Description	Adhesion G protein-coupled receptor E2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	14732393 - 14778541
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127507 (version 83.38)
Entrez gene	30817
UniProt	Q9UHX3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHX3
Antibodypedia	ADGRE2 antibodies

PROTEIN BROWSER

ADGRE2-001	ADGRE2-002	ADGRE2-003	ADGRE2-007	ADGRE2-008	ADGRE2-009	ADGRE2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRE2-001 ENSP00000472280 ENST00000596991	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	812 aa 89.5 kDa	Yes	7
ADGRE2-002 ENSP00000376692 ENST00000392965	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	765 aa 84.1 kDa	Yes	7
ADGRE2-003 ENSP00000319883 ENST00000315576	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	823 aa 90.5 kDa	Yes	7
ADGRE2-007 ENSP00000470725 ENST00000594294	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	774 aa 85.2 kDa	Yes	7
ADGRE2-008 ENSP00000472735 ENST00000594076	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	730 aa 80.3 kDa	Yes	7
ADGRE2-009 ENSP00000469277 ENST00000595839	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	681 aa 74.9 kDa	Yes	7
ADGRE2-010 ENSP00000471297 ENST00000601345	M0R0K5 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	831 aa 91.3 kDa	Yes	7

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.