Expression of ADGRE2 in cancer - Summary - The Human Protein Atlas

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ADGRE2

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	ADGRE2
Gene description	Adhesion G protein-coupled receptor E2
Protein class	CD markers G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL, HMC-1, U-937)
HPA (normal tissue):	Tissue enhanced (appendix, spleen)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	ADGRE2 (HGNC Symbol)
Synonyms	CD312, EMR2
Description	Adhesion G protein-coupled receptor E2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	14732393 - 14778541
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127507 (version 83.38)
Entrez gene	30817
UniProt	Q9UHX3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHX3
Antibodypedia	ADGRE2 antibodies

PROTEIN BROWSER

ADGRE2-001	ADGRE2-002	ADGRE2-003	ADGRE2-007	ADGRE2-008	ADGRE2-009	ADGRE2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRE2-001 ENSP00000472280 ENST00000596991	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	812 aa 89.5 kDa	Yes	7
ADGRE2-002 ENSP00000376692 ENST00000392965	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	765 aa 84.1 kDa	Yes	7
ADGRE2-003 ENSP00000319883 ENST00000315576	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	823 aa 90.5 kDa	Yes	7
ADGRE2-007 ENSP00000470725 ENST00000594294	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	774 aa 85.2 kDa	Yes	7
ADGRE2-008 ENSP00000472735 ENST00000594076	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	730 aa 80.3 kDa	Yes	7
ADGRE2-009 ENSP00000469277 ENST00000595839	Q9UHX3 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0031256 [leading edge membrane] GO:0032587 [ruffle membrane] GO:0035374 [chondroitin sulfate binding] GO:0071621 [granulocyte chemotaxis] Show all	681 aa 74.9 kDa	Yes	7
ADGRE2-010 ENSP00000471297 ENST00000601345	M0R0K5 [Direct mapping] Adhesion G protein-coupled receptor E2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	831 aa 91.3 kDa	Yes	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.