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ADGRE2

GENERAL INFORMATION

Gene name

 ADGRE2

Gene description

 Adhesion G protein-coupled receptor E2

Protein class

 CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix, spleen)
GTEx:Group enriched (lung, spleen)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ADGRE2 (HGNC Symbol)

Synonyms

 CD312, EMR2

Description

 Adhesion G protein-coupled receptor E2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 14732393 - 14778541

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127507 (version 83.38)

Entrez gene

 30817

UniProt

 Q9UHX3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHX3

Antibodypedia

 ADGRE2 antibodies

PROTEIN BROWSER
ADGRE2-001
ADGRE2-002
ADGRE2-003
ADGRE2-007
ADGRE2-008
ADGRE2-009
ADGRE2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADGRE2-001
ENSP00000472280
ENST00000596991
Q9UHX3 [Direct mapping]
Adhesion G protein-coupled receptor E2
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0031256 [leading edge membrane]
GO:0032587 [ruffle membrane]
GO:0035374 [chondroitin sulfate binding]
GO:0071621 [granulocyte chemotaxis]
Show all
 812 aa
89.5 kDa 		Yes 7
ADGRE2-002
ENSP00000376692
ENST00000392965
Q9UHX3 [Direct mapping]
Adhesion G protein-coupled receptor E2
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0031256 [leading edge membrane]
GO:0032587 [ruffle membrane]
GO:0035374 [chondroitin sulfate binding]
GO:0071621 [granulocyte chemotaxis]
Show all
 765 aa
84.1 kDa 		Yes 7
ADGRE2-003
ENSP00000319883
ENST00000315576
Q9UHX3 [Direct mapping]
Adhesion G protein-coupled receptor E2
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0031256 [leading edge membrane]
GO:0032587 [ruffle membrane]
GO:0035374 [chondroitin sulfate binding]
GO:0071621 [granulocyte chemotaxis]
Show all
 823 aa
90.5 kDa 		Yes 7
ADGRE2-007
ENSP00000470725
ENST00000594294
Q9UHX3 [Direct mapping]
Adhesion G protein-coupled receptor E2
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0031256 [leading edge membrane]
GO:0032587 [ruffle membrane]
GO:0035374 [chondroitin sulfate binding]
GO:0071621 [granulocyte chemotaxis]
Show all
 774 aa
85.2 kDa 		Yes 7
ADGRE2-008
ENSP00000472735
ENST00000594076
Q9UHX3 [Direct mapping]
Adhesion G protein-coupled receptor E2
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0031256 [leading edge membrane]
GO:0032587 [ruffle membrane]
GO:0035374 [chondroitin sulfate binding]
GO:0071621 [granulocyte chemotaxis]
Show all
 730 aa
80.3 kDa 		Yes 7
ADGRE2-009
ENSP00000469277
ENST00000595839
Q9UHX3 [Direct mapping]
Adhesion G protein-coupled receptor E2
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0031256 [leading edge membrane]
GO:0032587 [ruffle membrane]
GO:0035374 [chondroitin sulfate binding]
GO:0071621 [granulocyte chemotaxis]
Show all
 681 aa
74.9 kDa 		Yes 7
ADGRE2-010
ENSP00000471297
ENST00000601345
M0R0K5 [Direct mapping]
Adhesion G protein-coupled receptor E2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 831 aa
91.3 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.