Cell atlas - KRT17 - The Human Protein Atlas

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KRT17

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Intermediate filaments

Human cell
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	KRT17
Gene description	Keratin 17, type I
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the intermediate filaments.
RNA cell category	Group enriched (hTCEpi, SiHa)
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 3 antibodies. HPA000453 , HPA000539 , HPA045062
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (hTCEpi, SiHa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the intermediate filaments.

Main location

Intermediate filaments (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA045062	A-431	No staining
	HPA045062	U-2 OS	Intermediate filaments	Intensity
	HPA045062	U-251 MG	No staining
	HPA000453	A-431	Intermediate filaments
	HPA000453	U-2 OS	Intermediate filaments	Intensity
	HPA000539	A-431	Intermediate filaments	Intensity
	HPA000539	SiHa	Intermediate filaments

GENE INFORMATION
Gene name	KRT17 (HGNC Symbol)
Synonyms	PCHC1
Description	Keratin 17, type I (HGNC Symbol)
Entrez gene summary	This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	41619437 - 41624842
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128422 (version 83.38)
Entrez gene	3872
UniProt	Q04695 (UniProt - Evidence at protein level)
neXtProt	NX_Q04695
Antibodypedia	KRT17 antibodies

PROTEIN BROWSER

KRT17-001	KRT17-002	KRT17-005	KRT17-006	KRT17-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT17-001 ENSP00000308452 ENST00000311208	Q04695 [Direct mapping] Keratin, type I cytoskeletal 17 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002009 [morphogenesis of an epithelium] GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005882 [intermediate filament] GO:0007165 [signal transduction] GO:0008544 [epidermis development] GO:0030307 [positive regulation of cell growth] GO:0031069 [hair follicle morphogenesis] GO:0031424 [keratinization] GO:0032395 [MHC class II receptor activity] GO:0042289 [MHC class II protein binding] GO:0045109 [intermediate filament organization] GO:0045727 [positive regulation of translation] GO:0051798 [positive regulation of hair follicle development] GO:0070062 [extracellular exosome] GO:0071944 [cell periphery] Show all	432 aa 48.1 kDa	No	0
KRT17-002 ENSP00000468672 ENST00000463128	K7ESE1 [Direct mapping] Keratin, type I cytoskeletal 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	95 aa 11 kDa	No	0
KRT17-005 ENSP00000467418 ENST00000577817	K7EPJ9 [Direct mapping] Keratin, type I cytoskeletal 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	231 aa 24.9 kDa	No	0
KRT17-006 ENSP00000466166 ENST00000590038	K7ELP7 [Direct mapping] Keratin, type I cytoskeletal 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	49 aa 5.5 kDa	No	0
KRT17-201 ENSP00000441751 ENST00000540235	F5GWP8 [Direct mapping] Keratin, type I cytoskeletal 17 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005882 [intermediate filament] Show all	349 aa 40.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.