Expression of KRT17 in cancer - Summary

GENERAL INFORMATION
Gene name	KRT17
Gene description	Keratin 17, type I
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (hTCEpi, SiHa)
HPA (normal tissue):	Tissue enhanced (breast, seminal vesicle, urinary bladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic and membranous expression mainly in squamous epithelia, urinary bladder, salivary gland, breast, prostate and respiratory tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 4 antibodies. HPA000452 , HPA000453 , HPA045062 , CAB000029
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and renal cancer (unfavourable).
Breast cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000452	HPA000453	HPA045062	CAB000029

GENE INFORMATION
Gene name	KRT17 (HGNC Symbol)
Synonyms	PCHC1
Description	Keratin 17, type I (HGNC Symbol)
Entrez gene summary	This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	41619437 - 41624842
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128422 (version 83.38)
Entrez gene	3872
UniProt	Q04695 (UniProt - Evidence at protein level)
neXtProt	NX_Q04695
Antibodypedia	KRT17 antibodies

PROTEIN BROWSER

KRT17-001	KRT17-002	KRT17-005	KRT17-006	KRT17-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT17-001 ENSP00000308452 ENST00000311208	Q04695 [Direct mapping] Keratin, type I cytoskeletal 17 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002009 [morphogenesis of an epithelium] GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005882 [intermediate filament] GO:0007165 [signal transduction] GO:0008544 [epidermis development] GO:0030307 [positive regulation of cell growth] GO:0031069 [hair follicle morphogenesis] GO:0031424 [keratinization] GO:0032395 [MHC class II receptor activity] GO:0042289 [MHC class II protein binding] GO:0045109 [intermediate filament organization] GO:0045727 [positive regulation of translation] GO:0051798 [positive regulation of hair follicle development] GO:0070062 [extracellular exosome] GO:0071944 [cell periphery] Show all	432 aa 48.1 kDa	No	0
KRT17-002 ENSP00000468672 ENST00000463128	K7ESE1 [Direct mapping] Keratin, type I cytoskeletal 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	95 aa 11 kDa	No	0
KRT17-005 ENSP00000467418 ENST00000577817	K7EPJ9 [Direct mapping] Keratin, type I cytoskeletal 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	231 aa 24.9 kDa	No	0
KRT17-006 ENSP00000466166 ENST00000590038	K7ELP7 [Direct mapping] Keratin, type I cytoskeletal 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	49 aa 5.5 kDa	No	0
KRT17-201 ENSP00000441751 ENST00000540235	F5GWP8 [Direct mapping] Keratin, type I cytoskeletal 17 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005882 [intermediate filament] Show all	349 aa 40.3 kDa	No	0