Expression of OPN1SW in cancer - Summary - The Human Protein Atlas

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OPN1SW

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OPN1SW
Gene description	Opsin 1 (cone pigments), short-wave-sensitive
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-87 MG)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in rods in retina.

ANTIBODY IHC RELIABILITY
Data reliability description	No internal RNA expression data available for correlation. External characterization data supports antibody staining but no internal RNA data available for correlation. Paired antibodies with high similarity supports the protein profile.
Reliability score	Supported based on 2 antibodies. HPA013562 , HPA014083
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), stomach cancer (unfavourable), liver cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Stomach cancer p<0.001 Liver cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013562	HPA014083

GENE INFORMATION
Gene name	OPN1SW (HGNC Symbol)
Synonyms	BCP, BOP, CBT
Description	Opsin 1 (cone pigments), short-wave-sensitive (HGNC Symbol)
Entrez gene summary	This gene belongs to the G-protein coupled receptor 1 family, opsin subfamily. It encodes the blue cone pigment gene which is one of three types of cone photoreceptors responsible for normal color vision. Defects in this gene are the cause of tritan color blindness (tritanopia). Affected individuals lack blue and yellow sensory mechanisms while retaining those for red and green. Defective blue vision is characteristic. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q32.1
Chromosome location (bp)	128772491 - 128775790
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128617 (version 83.38)
Entrez gene	611
UniProt	P03999 (UniProt - Evidence at protein level)
neXtProt	NX_P03999
Antibodypedia	OPN1SW antibodies

PROTEIN BROWSER

OPN1SW-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OPN1SW-001 ENSP00000249389 ENST00000249389	P03999 [Direct mapping] Short-wave-sensitive opsin 1 Q0PJU0 [Target identity:100%; Query identity:100%] Opsin 1 (Cone pigments), short-wave-sensitive (Color blindness, tritan); Opsin 1 short-wave-sensitive Show all	G-protein coupled receptors GPCRs excl olfactory receptors Opsins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0001750 [photoreceptor outer segment] GO:0004872 [receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007601 [visual perception] GO:0007602 [phototransduction] GO:0007603 [phototransduction, visible light] GO:0009881 [photoreceptor activity] GO:0016021 [integral component of membrane] GO:0018298 [protein-chromophore linkage] GO:0042622 [photoreceptor outer segment membrane] Show all	348 aa 39.1 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.