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Most adenocarcinomas and testicular cancers showed moderate membranous immunoreactivity often combined with cytoplasmic staining. A few cases of endometrial cancer showed strong membranous staining. Remaining malignancies were in general weakly stained or negative.
Prostate cancers, several cases of breast and endometrial cancers as well as a few cases of testicular and liver cancers exhibited moderate membranous immunoreactivity. Remaining tumors were mainly negative.
GENE INFORMATION
Gene name
PVRL2 (HGNC Symbol)
Synonyms
CD112, HVEB, PRR2, PVRR2
Description
Poliovirus receptor-related 2 (herpesvirus entry mediator B) (HGNC Symbol)
Entrez gene summary
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]