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PVRL2

GENERAL INFORMATION

Gene name

 PVRL2

Gene description

 Poliovirus receptor-related 2 (herpesvirus entry mediator B)

Protein class

 CD markers
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA012759 , CAB026138
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PVRL2 (HGNC Symbol)

Synonyms

 CD112, HVEB, PRR2, PVRR2

Description

 Poliovirus receptor-related 2 (herpesvirus entry mediator B) (HGNC Symbol)

Entrez gene summary

 This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 44846175 - 44889228

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130202 (version 83.38)

Entrez gene

 5819

UniProt

 Q92692 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92692

Antibodypedia

 PVRL2 antibodies

PROTEIN BROWSER
PVRL2-001
PVRL2-002
PVRL2-003
PVRL2-005
PVRL2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PVRL2-001
ENSP00000252485
ENST00000252485
Q92692 [Direct mapping]
Nectin-2
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002860 [positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target]
GO:0002891 [positive regulation of immunoglobulin mediated immune response]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005925 [focal adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007165 [signal transduction]
GO:0007286 [spermatid development]
GO:0008037 [cell recognition]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0019064 [fusion of virus membrane with host plasma membrane]
GO:0033005 [positive regulation of mast cell activation]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042271 [susceptibility to natural killer cell mediated cytotoxicity]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044406 [adhesion of symbiont to host]
GO:0045216 [cell-cell junction organization]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0046596 [regulation of viral entry into host cell]
GO:0046814 [coreceptor-mediated virion attachment to host cell]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0060370 [susceptibility to T cell mediated cytotoxicity]
GO:0070062 [extracellular exosome]
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 479 aa
51.4 kDa 		Yes 1
PVRL2-002
ENSP00000252483
ENST00000252483
Q92692 [Direct mapping]
Nectin-2
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001675 [acrosome assembly]
GO:0002860 [positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target]
GO:0002891 [positive regulation of immunoglobulin mediated immune response]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005925 [focal adhesion]
GO:0007010 [cytoskeleton organization]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007165 [signal transduction]
GO:0007286 [spermatid development]
GO:0007289 [spermatid nucleus differentiation]
GO:0008037 [cell recognition]
GO:0009566 [fertilization]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0019064 [fusion of virus membrane with host plasma membrane]
GO:0030382 [sperm mitochondrion organization]
GO:0032990 [cell part morphogenesis]
GO:0033005 [positive regulation of mast cell activation]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042271 [susceptibility to natural killer cell mediated cytotoxicity]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044406 [adhesion of symbiont to host]
GO:0044782 [cilium organization]
GO:0045216 [cell-cell junction organization]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0046596 [regulation of viral entry into host cell]
GO:0046814 [coreceptor-mediated virion attachment to host cell]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0051654 [establishment of mitochondrion localization]
GO:0060370 [susceptibility to T cell mediated cytotoxicity]
GO:0070062 [extracellular exosome]
Show all
 538 aa
57.7 kDa 		Yes 1
PVRL2-003
ENSP00000465587
ENST00000591581
K7EKE8 [Direct mapping]
Nectin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 210 aa
22.6 kDa 		No 0
PVRL2-005
ENSP00000468305
ENST00000592018
K7ERL3 [Direct mapping]
Nectin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 54 aa
6.1 kDa 		No 0
PVRL2-006
ENSP00000465511
ENST00000585601
K7EK87 [Direct mapping]
Nectin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 56 aa
6.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.