We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
BST2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

BST2

Gene description

Bone marrow stromal cell antigen 2

Protein class

CD markers
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA017060
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), testis cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001
Testis cancer p<0.001
Breast cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA017060

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer tissues displayed moderate, often granular, cytoplasmic staining combined with membranous positivity. Colorectal, breast and endometrial cancers were strongly stained in a majority of cases. Testicular cancers were weakly stained or negative.

GENE INFORMATION

Gene name

BST2 (HGNC Symbol)

Synonyms

CD317, tetherin

Description

Bone marrow stromal cell antigen 2 (HGNC Symbol)

Entrez gene summary

Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.11

Chromosome location (bp)

17402939 - 17405648

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130303 (version 83.38)

Entrez gene

684

UniProt

Q10589 (UniProt - Evidence at protein level)

neXtProt

NX_Q10589

Antibodypedia

BST2 antibodies

PROTEIN BROWSER

BST2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BST2-001
ENSP00000252593
ENST00000252593
Q10589 [Direct mapping]
Bone marrow stromal antigen 2
A0A024R7H5 [Target identity:100%; Query identity:100%]
Bone marrow stromal cell antigen 2, isoform CRA_a
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002737 [negative regulation of plasmacytoid dendritic cell cytokine production]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005770 [late endosome]
GO:0005771 [multivesicular body]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006959 [humoral immune response]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0008191 [metalloendopeptidase inhibitor activity]
GO:0008283 [cell proliferation]
GO:0009615 [response to virus]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0031225 [anchored component of membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034341 [response to interferon-gamma]
GO:0035455 [response to interferon-alpha]
GO:0035456 [response to interferon-beta]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0070062 [extracellular exosome]
GO:1901253 [negative regulation of intracellular transport of viral material]
Show all
180 aa
19.8 kDa
No 1

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.