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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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BST2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

BST2

Gene description

Bone marrow stromal cell antigen 2

Protein class

CD markers
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA017060
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
N/A
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

BST2 (HGNC Symbol)

Synonyms

CD317, tetherin

Description

Bone marrow stromal cell antigen 2 (HGNC Symbol)

Entrez gene summary

Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.11

Chromosome location (bp)

17402939 - 17405648

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130303 (version 83.38)

Entrez gene

684

UniProt

Q10589 (UniProt - Evidence at protein level)

neXtProt

NX_Q10589

Antibodypedia

BST2 antibodies

PROTEIN BROWSER

BST2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BST2-001
ENSP00000252593
ENST00000252593
Q10589 [Direct mapping]
Bone marrow stromal antigen 2
A0A024R7H5 [Target identity:100%; Query identity:100%]
Bone marrow stromal cell antigen 2, isoform CRA_a
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002737 [negative regulation of plasmacytoid dendritic cell cytokine production]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005770 [late endosome]
GO:0005771 [multivesicular body]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006959 [humoral immune response]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0008191 [metalloendopeptidase inhibitor activity]
GO:0008283 [cell proliferation]
GO:0009615 [response to virus]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0031225 [anchored component of membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034341 [response to interferon-gamma]
GO:0035455 [response to interferon-alpha]
GO:0035456 [response to interferon-beta]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0070062 [extracellular exosome]
GO:1901253 [negative regulation of intracellular transport of viral material]
Show all
180 aa
19.8 kDa
No 1

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