Cell atlas - SLC35D2 - The Human Protein Atlas

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SLC35D2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	SLC35D2
Gene description	Solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (validated)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA064047
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064047	CACO-2	No staining
	HPA064047	Hep G2	Golgi apparatus
	HPA064047	U-2 OS	Golgi apparatus

GENE INFORMATION
Gene name	SLC35D2 (HGNC Symbol)
Synonyms	SQV7L, UGTrel8
Description	Solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 (HGNC Symbol)
Entrez gene summary	Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]
Chromosome	9
Cytoband	q22.32
Chromosome location (bp)	96320706 - 96383710
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130958 (version 83.38)
Entrez gene	11046
UniProt	Q76EJ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q76EJ3
Antibodypedia	SLC35D2 antibodies

PROTEIN BROWSER

SLC35D2-001	SLC35D2-004	SLC35D2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC35D2-001 ENSP00000253270 ENST00000253270	Q76EJ3 [Direct mapping] UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter A0A024R9N5 [Target identity:100%; Query identity:100%] Solute carrier family 35, member D2, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005575 [cellular_component] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0008150 [biological_process] GO:0008643 [carbohydrate transport] GO:0015165 [pyrimidine nucleotide-sugar transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016021 [integral component of membrane] GO:0018146 [keratan sulfate biosynthetic process] GO:0030203 [glycosaminoglycan metabolic process] GO:0042339 [keratan sulfate metabolic process] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0090481 [pyrimidine nucleotide-sugar transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	337 aa 36.7 kDa	No	>9
SLC35D2-004 ENSP00000364406 ENST00000375257	Q5VZJ2 [Direct mapping] UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0015165 [pyrimidine nucleotide-sugar transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016021 [integral component of membrane] GO:0090481 [pyrimidine nucleotide-sugar transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	163 aa 17.4 kDa	No	5
SLC35D2-201 ENSP00000364408 ENST00000375259	Q76EJ3 [Direct mapping] UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005575 [cellular_component] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0008150 [biological_process] GO:0008643 [carbohydrate transport] GO:0015165 [pyrimidine nucleotide-sugar transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016021 [integral component of membrane] GO:0018146 [keratan sulfate biosynthetic process] GO:0030203 [glycosaminoglycan metabolic process] GO:0042339 [keratan sulfate metabolic process] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0090481 [pyrimidine nucleotide-sugar transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	249 aa 26.7 kDa	No	8

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.