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SLC35D2

GENERAL INFORMATION

Gene name

 SLC35D2

Gene description

 Solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA064047
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA064047

GENE INFORMATION

Gene name

 SLC35D2 (HGNC Symbol)

Synonyms

 SQV7L, UGTrel8

Description

 Solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 (HGNC Symbol)

Entrez gene summary

 Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]

Chromosome

 9

Cytoband

 q22.32

Chromosome location (bp)

 96320706 - 96383710

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130958 (version 83.38)

Entrez gene

 11046

UniProt

 Q76EJ3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q76EJ3

Antibodypedia

 SLC35D2 antibodies

PROTEIN BROWSER
SLC35D2-001
SLC35D2-004
SLC35D2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC35D2-001
ENSP00000253270
ENST00000253270
Q76EJ3 [Direct mapping]
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
A0A024R9N5 [Target identity:100%; Query identity:100%]
Solute carrier family 35, member D2, isoform CRA_a
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
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GO:0000139 [Golgi membrane]
GO:0005338 [nucleotide-sugar transmembrane transporter activity]
GO:0005575 [cellular_component]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0008150 [biological_process]
GO:0008643 [carbohydrate transport]
GO:0015165 [pyrimidine nucleotide-sugar transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0016021 [integral component of membrane]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0042339 [keratan sulfate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0090481 [pyrimidine nucleotide-sugar transmembrane transport]
GO:0098656 [anion transmembrane transport]
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 337 aa
36.7 kDa 		No >9
SLC35D2-004
ENSP00000364406
ENST00000375257
Q5VZJ2 [Direct mapping]
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0015165 [pyrimidine nucleotide-sugar transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0016021 [integral component of membrane]
GO:0090481 [pyrimidine nucleotide-sugar transmembrane transport]
GO:0098656 [anion transmembrane transport]
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 163 aa
17.4 kDa 		No 5
SLC35D2-201
ENSP00000364408
ENST00000375259
Q76EJ3 [Direct mapping]
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0005338 [nucleotide-sugar transmembrane transporter activity]
GO:0005575 [cellular_component]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0008150 [biological_process]
GO:0008643 [carbohydrate transport]
GO:0015165 [pyrimidine nucleotide-sugar transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0016021 [integral component of membrane]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0042339 [keratan sulfate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0090481 [pyrimidine nucleotide-sugar transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 249 aa
26.7 kDa 		No 8

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.