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ACLY

GENERAL INFORMATION

Gene name

 ACLY

Gene description

 ATP citrate lyase

Protein class

 Cancer-related genes
Citric acid cycle related proteins
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 5 antibodies.
HPA022434 , HPA022953 , HPA022959 , HPA028758 , CAB007783
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and liver cancer (unfavourable).
Cervical cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA022434
HPA022953
HPA022959
HPA028758
CAB007783

GENE INFORMATION

Gene name

 ACLY (HGNC Symbol)

Synonyms

 ACL, ATPCL, CLATP

Description

 ATP citrate lyase (HGNC Symbol)

Entrez gene summary

 ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41866908 - 41930542

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131473 (version 83.38)

Entrez gene

 47

UniProt

 P53396 (UniProt - Evidence at protein level)

neXtProt

 NX_P53396

Antibodypedia

 ACLY antibodies

PROTEIN BROWSER
ACLY-001
ACLY-002
ACLY-003
ACLY-004
ACLY-005
ACLY-006
ACLY-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACLY-001
ENSP00000253792
ENST00000352035
P53396 [Direct mapping]
ATP-citrate synthase
A0A024R1T9 [Target identity:100%; Query identity:100%]
ATP citrate lyase, isoform CRA_b
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003878 [ATP citrate synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006085 [acetyl-CoA biosynthetic process]
GO:0006101 [citrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006629 [lipid metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0009346 [citrate lyase complex]
GO:0015936 [coenzyme A metabolic process]
GO:0016020 [membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
Show all
 1101 aa
120.8 kDa 		No 0
ACLY-002
ENSP00000377474
ENST00000393896
P53396 [Direct mapping]
ATP-citrate synthase
A0A024R1Y2 [Target identity:100%; Query identity:100%]
ATP citrate lyase, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003878 [ATP citrate synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006085 [acetyl-CoA biosynthetic process]
GO:0006101 [citrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0009346 [citrate lyase complex]
GO:0015936 [coenzyme A metabolic process]
GO:0016020 [membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
Show all
 1091 aa
119.8 kDa 		No 0
ACLY-003
ENSP00000466259
ENST00000590151
P53396 [Direct mapping]
ATP-citrate synthase
A0A024R1T9 [Target identity:100%; Query identity:100%]
ATP citrate lyase, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003878 [ATP citrate synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006085 [acetyl-CoA biosynthetic process]
GO:0006101 [citrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0009346 [citrate lyase complex]
GO:0015936 [coenzyme A metabolic process]
GO:0016020 [membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
Show all
 1101 aa
120.8 kDa 		No 0
ACLY-004
ENSP00000445349
ENST00000537919
P53396 [Direct mapping]
ATP-citrate synthase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003878 [ATP citrate synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006085 [acetyl-CoA biosynthetic process]
GO:0006112 [energy reserve metabolic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0009346 [citrate lyase complex]
GO:0015936 [coenzyme A metabolic process]
GO:0016020 [membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
Show all
 830 aa
91.1 kDa 		No 0
ACLY-005
ENSP00000468705
ENST00000592970
K7ESG8 [Direct mapping]
ATP-citrate synthase
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 109 aa
12.3 kDa 		No 0
ACLY-006
ENSP00000464717
ENST00000590770
K7EIE7 [Direct mapping]
ATP-citrate synthase
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 133 aa
14.2 kDa 		No 0
ACLY-201
ENSP00000345398
ENST00000353196
P53396 [Direct mapping]
ATP-citrate synthase
A0A024R1Y2 [Target identity:100%; Query identity:100%]
ATP citrate lyase, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003878 [ATP citrate synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006085 [acetyl-CoA biosynthetic process]
GO:0006101 [citrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0009346 [citrate lyase complex]
GO:0015936 [coenzyme A metabolic process]
GO:0016020 [membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
Show all
 1091 aa
119.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.