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RAP1GAP2

GENERAL INFORMATION

Gene name

 RAP1GAP2

Gene description

 RAP1 GTPase activating protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SH-SY5Y)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA022148 , HPA022896
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022148
HPA022896

GENE INFORMATION

Gene name

 RAP1GAP2 (HGNC Symbol)

Synonyms

 GARNL4, KIAA1039

Description

 RAP1 GTPase activating protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 2777056 - 3037739

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132359 (version 83.38)

Entrez gene

 23108

UniProt

 Q684P5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q684P5

Antibodypedia

 RAP1GAP2 antibodies

PROTEIN BROWSER
RAP1GAP2-001
RAP1GAP2-002
RAP1GAP2-003
RAP1GAP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAP1GAP2-001
ENSP00000254695
ENST00000254695
Q684P5 [Direct mapping]
Rap1 GTPase-activating protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008361 [regulation of cell size]
GO:0010977 [negative regulation of neuron projection development]
GO:0031965 [nuclear membrane]
GO:0043005 [neuron projection]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
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 730 aa
80.1 kDa 		No 0
RAP1GAP2-002
ENSP00000389824
ENST00000366401
Q684P5 [Direct mapping]
Rap1 GTPase-activating protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008361 [regulation of cell size]
GO:0031965 [nuclear membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 715 aa
78.4 kDa 		No 0
RAP1GAP2-003
ENSP00000439688
ENST00000540393
Q684P5 [Direct mapping]
Rap1 GTPase-activating protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008361 [regulation of cell size]
GO:0031965 [nuclear membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 711 aa
77.9 kDa 		No 0
RAP1GAP2-201
ENSP00000444890
ENST00000542807
Q684P5 [Direct mapping]
Rap1 GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008361 [regulation of cell size]
GO:0031965 [nuclear membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 730 aa
80.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.