Fields »
ABOUT
HELP
BLOG
RAP1GAP2

GENERAL INFORMATION

Gene name

 RAP1GAP2

Gene description

 RAP1 GTPase activating protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA022148 , HPA022896
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

 RAP1GAP2 (HGNC Symbol)

Synonyms

 GARNL4, KIAA1039

Description

 RAP1 GTPase activating protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 2777056 - 3037739

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132359 (version 83.38)

Entrez gene

 23108

UniProt

 Q684P5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q684P5

Antibodypedia

 RAP1GAP2 antibodies

PROTEIN BROWSER
RAP1GAP2-001
RAP1GAP2-002
RAP1GAP2-003
RAP1GAP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAP1GAP2-001
ENSP00000254695
ENST00000254695
Q684P5 [Direct mapping]
Rap1 GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008361 [regulation of cell size]
GO:0010977 [negative regulation of neuron projection development]
GO:0031965 [nuclear membrane]
GO:0043005 [neuron projection]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 730 aa
80.1 kDa 		No 0
RAP1GAP2-002
ENSP00000389824
ENST00000366401
Q684P5 [Direct mapping]
Rap1 GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008361 [regulation of cell size]
GO:0031965 [nuclear membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 715 aa
78.4 kDa 		No 0
RAP1GAP2-003
ENSP00000439688
ENST00000540393
Q684P5 [Direct mapping]
Rap1 GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008361 [regulation of cell size]
GO:0031965 [nuclear membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 711 aa
77.9 kDa 		No 0
RAP1GAP2-201
ENSP00000444890
ENST00000542807
Q684P5 [Direct mapping]
Rap1 GTPase-activating protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008361 [regulation of cell size]
GO:0031965 [nuclear membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 730 aa
80.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.