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GRSF1

GENERAL INFORMATION

Gene name

 GRSF1

Gene description

 G-rich RNA sequence binding factor 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA036984 , HPA036985
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), colorectal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036984
HPA036985

GENE INFORMATION

Gene name

 GRSF1

Synonyms

Description

 G-rich RNA sequence binding factor 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 70815782 - 70839945

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132463 (version 83.38)

Entrez gene

 2926

UniProt

 Q12849 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12849

Antibodypedia

 GRSF1 antibodies

PROTEIN BROWSER
GRSF1-001
GRSF1-004
GRSF1-005
GRSF1-006
GRSF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRSF1-001
ENSP00000254799
ENST00000254799
Q12849 [Direct mapping]
G-rich sequence factor 1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006378 [mRNA polyadenylation]
GO:0008033 [tRNA processing]
GO:0009952 [anterior/posterior pattern specification]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0035770 [ribonucleoprotein granule]
GO:0042645 [mitochondrial nucleoid]
GO:0044822 [poly(A) RNA binding]
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 480 aa
53.1 kDa 		No 0
GRSF1-004
ENSP00000427354
ENST00000499044
H0YAK1 [Direct mapping]
G-rich sequence factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005739 [mitochondrion]
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 453 aa
51 kDa 		No 0
GRSF1-005
ENSP00000421789
ENST00000514161
H0Y8R1 [Direct mapping]
G-rich sequence factor 1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 417 aa
47.3 kDa 		No 0
GRSF1-006
ENSP00000425430
ENST00000502323
Q12849 [Direct mapping]
G-rich sequence factor 1
A0A024RD99 [Target identity:100%; Query identity:100%]
G-rich RNA sequence binding factor 1, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006378 [mRNA polyadenylation]
GO:0008033 [tRNA processing]
GO:0035770 [ribonucleoprotein granule]
GO:0042645 [mitochondrial nucleoid]
GO:0044822 [poly(A) RNA binding]
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 318 aa
36.6 kDa 		No 0
GRSF1-201
ENSP00000443380
ENST00000545193
F5H5I6 [Direct mapping]
G-rich sequence factor 1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005739 [mitochondrion]
Show all
 424 aa
48 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.