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VPS4A

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GENERAL INFORMATION

Gene name

 VPS4A

Gene description

 Vacuolar protein sorting 4 homolog A (S. cerevisiae)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the midbody. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Midbody (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA060092
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the midbody. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Midbody (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA060092 SiHa Midbody Intensity Intensity
HPA060092 U-2 OS No staining    

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition

GENE INFORMATION

Gene name

 VPS4A (HGNC Symbol)

Synonyms

 FLJ22197, SKD1, SKD1A, SKD2, VPS4, VPS4-1

Description

 Vacuolar protein sorting 4 homolog A (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 69311356 - 69326939

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132612 (version 83.38)

Entrez gene

 27183

UniProt

 Q9UN37 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UN37

Antibodypedia

 VPS4A antibodies

PROTEIN BROWSER
VPS4A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VPS4A-002
ENSP00000254950
ENST00000254950
Q9UN37 [Direct mapping]
Vacuolar protein sorting-associated protein 4A
A0A024R705 [Target identity:100%; Query identity:100%]
Vacuolar protein sorting 4A (Yeast), isoform CRA_c
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000815 [ESCRT III complex]
GO:0000920 [cell separation after cytokinesis]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005774 [vacuolar membrane]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006900 [membrane budding]
GO:0006997 [nucleus organization]
GO:0007033 [vacuole organization]
GO:0007080 [mitotic metaphase plate congression]
GO:0008022 [protein C-terminus binding]
GO:0009838 [abscission]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0016887 [ATPase activity]
GO:0019058 [viral life cycle]
GO:0019076 [viral release from host cell]
GO:0019904 [protein domain specific binding]
GO:0030496 [midbody]
GO:0031902 [late endosome membrane]
GO:0032367 [intracellular cholesterol transport]
GO:0032466 [negative regulation of cytokinesis]
GO:0032880 [regulation of protein localization]
GO:0034058 [endosomal vesicle fusion]
GO:0039702 [viral budding via host ESCRT complex]
GO:0042623 [ATPase activity, coupled]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051301 [cell division]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072319 [vesicle uncoating]
GO:0090543 [Flemming body]
GO:0090611 [ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway]
GO:1902188 [positive regulation of viral release from host cell]
GO:1903076 [regulation of protein localization to plasma membrane]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903774 [positive regulation of viral budding via host ESCRT complex]
GO:1903902 [positive regulation of viral life cycle]
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 437 aa
48.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.