Cell atlas - BCAN - The Human Protein Atlas

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BCAN

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	BCAN
Gene description	Brevican
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (K-562, U-266/84, HDLM-2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (K-562, U-266/84, HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	BCAN (HGNC Symbol)
Synonyms	BEHAB, CSPG7, MGC13038
Description	Brevican (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	156641390 - 156659532
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132692 (version 83.38)
Entrez gene	63827
UniProt	Q96GW7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96GW7
Antibodypedia	BCAN antibodies

PROTEIN BROWSER

BCAN-001	BCAN-002	BCAN-006	BCAN-007	BCAN-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCAN-001 ENSP00000331210 ENST00000329117	Q96GW7 [Direct mapping] Brevican core protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0021766 [hippocampus development] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0030246 [carbohydrate binding] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0045202 [synapse] GO:0048168 [regulation of neuronal synaptic plasticity] Show all	911 aa 99.1 kDa	Yes	0
BCAN-002 ENSP00000354925 ENST00000361588	Q96GW7 [Direct mapping] Brevican core protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0030246 [carbohydrate binding] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] Show all	671 aa 71.7 kDa	Yes	0
BCAN-006 ENSP00000401709 ENST00000424639	Q5T3I6 [Direct mapping] Brevican core protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	231 aa 24.9 kDa	Yes	0
BCAN-007 ENSP00000389898 ENST00000457777	Q5T3I7 [Direct mapping] Brevican core protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	213 aa 23 kDa	Yes	0
BCAN-008 ENSP00000392731 ENST00000441358	Q5T3I8 [Direct mapping] Brevican core protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	145 aa 15.7 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.