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BCAN

GENERAL INFORMATION

Gene name

 BCAN

Gene description

 Brevican

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:Tissue enhanced (brain, caudate, cerebellum, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 High and selective expression in neuropil of the CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA007865 , CAB025862
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, caudate, cerebellum, hippocampus)

GENE INFORMATION

Gene name

 BCAN (HGNC Symbol)

Synonyms

 BEHAB, CSPG7, MGC13038

Description

 Brevican (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 156641390 - 156659532

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132692 (version 83.38)

Entrez gene

 63827

UniProt

 Q96GW7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96GW7

Antibodypedia

 BCAN antibodies

PROTEIN BROWSER
BCAN-001
BCAN-002
BCAN-006
BCAN-007
BCAN-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCAN-001
ENSP00000331210
ENST00000329117
Q96GW7 [Direct mapping]
Brevican core protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007417 [central nervous system development]
GO:0021766 [hippocampus development]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0030246 [carbohydrate binding]
GO:0030425 [dendrite]
GO:0031225 [anchored component of membrane]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0048168 [regulation of neuronal synaptic plasticity]
Show all
 911 aa
99.1 kDa 		Yes 0
BCAN-002
ENSP00000354925
ENST00000361588
Q96GW7 [Direct mapping]
Brevican core protein
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007417 [central nervous system development]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0030246 [carbohydrate binding]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
Show all
 671 aa
71.7 kDa 		Yes 0
BCAN-006
ENSP00000401709
ENST00000424639
Q5T3I6 [Direct mapping]
Brevican core protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0005540 [hyaluronic acid binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0007155 [cell adhesion]
GO:0007417 [central nervous system development]
Show all
 231 aa
24.9 kDa 		Yes 0
BCAN-007
ENSP00000389898
ENST00000457777
Q5T3I7 [Direct mapping]
Brevican core protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0007155 [cell adhesion]
GO:0007417 [central nervous system development]
Show all
 213 aa
23 kDa 		Yes 0
BCAN-008
ENSP00000392731
ENST00000441358
Q5T3I8 [Direct mapping]
Brevican core protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0007155 [cell adhesion]
GO:0007417 [central nervous system development]
Show all
 145 aa
15.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.