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A majority of malignant cells were negative. A few malignant gliomas and melanomas showed strong cytoplasmic positivity. Neuropil was distinctly stained.
GENE INFORMATION
Gene name
BCAN (HGNC Symbol)
Synonyms
BEHAB, CSPG7, MGC13038
Description
Brevican (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)