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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CRP
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CRP

Gene description

C-reactive protein, pentraxin-related

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (EFO-21, HDLM-2, U-2 OS, U-266/84)
HPA (normal tissue):Group enriched (gallbladder, liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Extracellular deposits in several tissues. Cytoplasmic expression in liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 3 antibodies.
HPA027367 , HPA027396 , CAB005036
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA027367
HPA027396
CAB005036

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Liver cancers showed moderate to strong cytoplasmic immunoreactivity. The remaining normal cells were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Liver cancers and several renal cancers showed moderate to strong cytoplasmic positivity. Several pancreatic, gastric, urothelial, skin and lung cancer were moderately stained. Remaining malignancies were negative or weakly stained.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several liver and pancreatic cancers as well as cases of urothelial, renal and lung cancers displayed moderate to strong cytoplasmic immunoreactivity. Remaining malignancies were generally negative.

GENE INFORMATION

Gene name

CRP (HGNC Symbol)

Synonyms

PTX1

Description

C-reactive protein, pentraxin-related (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

Chromosome

1

Cytoband

q23.2

Chromosome location (bp)

159712289 - 159714589

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132693 (version 83.38)

Entrez gene

1401

UniProt

P02741 (UniProt - Evidence at protein level)

neXtProt

NX_P02741

Antibodypedia

CRP antibodies

PROTEIN BROWSER

CRP-001
CRP-002
CRP-003
CRP-004
CRP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRP-001
ENSP00000255030
ENST00000255030
P02741 [Direct mapping]
C-reactive protein C-reactive protein(1-205)
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001849 [complement component C1q binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006953 [acute-phase response]
GO:0006954 [inflammatory response]
GO:0008228 [opsonization]
GO:0010628 [positive regulation of gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010888 [negative regulation of lipid storage]
GO:0030169 [low-density lipoprotein particle binding]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033265 [choline binding]
GO:0045908 [negative regulation of vasodilation]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
GO:2000482 [regulation of interleukin-8 secretion]
Show all
224 aa
25 kDa
Yes 0
CRP-002
ENSP00000357093
ENST00000368112
P02741 [Direct mapping]
C-reactive protein C-reactive protein(1-205)
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001849 [complement component C1q binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006953 [acute-phase response]
GO:0006954 [inflammatory response]
GO:0008228 [opsonization]
GO:0010628 [positive regulation of gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010888 [negative regulation of lipid storage]
GO:0030169 [low-density lipoprotein particle binding]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033265 [choline binding]
GO:0045908 [negative regulation of vasodilation]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
GO:2000482 [regulation of interleukin-8 secretion]
Show all
91 aa
10.4 kDa
Yes 0
CRP-003
ENSP00000357091
ENST00000368110
Q5VVP7 [Direct mapping]
C-reactive protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
102 aa
11.6 kDa
Yes 0
CRP-004
ENSP00000357092
ENST00000368111
Q5VVP7 [Direct mapping]
C-reactive protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
102 aa
11.6 kDa
Yes 0
CRP-201
ENSP00000402788
ENST00000437342
C9JRE9 [Direct mapping]
C-reactive protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
46 aa
5.4 kDa
No 0

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