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CRP

GENERAL INFORMATION

Gene name

 CRP

Gene description

 C-reactive protein, pentraxin-related

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (gallbladder, liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Extracellular deposits in several tissues. Cytoplasmic expression in liver.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 3 antibodies.
HPA027367 , HPA027396 , CAB005036
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Breast
N/A
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (gallbladder, liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 CRP (HGNC Symbol)

Synonyms

 PTX1

Description

 C-reactive protein, pentraxin-related (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

Chromosome

 1

Cytoband

 q23.2

Chromosome location (bp)

 159712289 - 159714589

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132693 (version 83.38)

Entrez gene

 1401

UniProt

 P02741 (UniProt - Evidence at protein level)

neXtProt

 NX_P02741

Antibodypedia

 CRP antibodies

PROTEIN BROWSER
CRP-001
CRP-002
CRP-003
CRP-004
CRP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRP-001
ENSP00000255030
ENST00000255030
P02741 [Direct mapping]
C-reactive protein C-reactive protein(1-205)
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001849 [complement component C1q binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006953 [acute-phase response]
GO:0006954 [inflammatory response]
GO:0008228 [opsonization]
GO:0010628 [positive regulation of gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010888 [negative regulation of lipid storage]
GO:0030169 [low-density lipoprotein particle binding]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033265 [choline binding]
GO:0045908 [negative regulation of vasodilation]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
GO:2000482 [regulation of interleukin-8 secretion]
Show all
 224 aa
25 kDa 		Yes 0
CRP-002
ENSP00000357093
ENST00000368112
P02741 [Direct mapping]
C-reactive protein C-reactive protein(1-205)
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001849 [complement component C1q binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006953 [acute-phase response]
GO:0006954 [inflammatory response]
GO:0008228 [opsonization]
GO:0010628 [positive regulation of gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010888 [negative regulation of lipid storage]
GO:0030169 [low-density lipoprotein particle binding]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033265 [choline binding]
GO:0045908 [negative regulation of vasodilation]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
GO:2000482 [regulation of interleukin-8 secretion]
Show all
 91 aa
10.4 kDa 		Yes 0
CRP-003
ENSP00000357091
ENST00000368110
Q5VVP7 [Direct mapping]
C-reactive protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 102 aa
11.6 kDa 		Yes 0
CRP-004
ENSP00000357092
ENST00000368111
Q5VVP7 [Direct mapping]
C-reactive protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 102 aa
11.6 kDa 		Yes 0
CRP-201
ENSP00000402788
ENST00000437342
C9JRE9 [Direct mapping]
C-reactive protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 46 aa
5.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.