Expression of EPHB2 in cancer - Summary - The Human Protein Atlas

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EPHB2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EPHB2
Gene description	EPH receptor B2
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer)
HPA (cell line):	Cell line enhanced (HUVEC TERT2, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including neurons.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending restaining.
Reliability score	Approved based on 1 antibody. CAB013647
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and colorectal cancer (favourable).
Endometrial cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB013647

GENE INFORMATION
Gene name	EPHB2 (HGNC Symbol)
Synonyms	DRT, EPHT3, ERK, Hek5, Tyro5
Description	EPH receptor B2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	22710839 - 22921500
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133216 (version 83.38)
Entrez gene	2048
UniProt	P29323 (UniProt - Evidence at protein level)
neXtProt	NX_P29323
Antibodypedia	EPHB2 antibodies

PROTEIN BROWSER

EPHB2-001	EPHB2-002	EPHB2-003	EPHB2-004	EPHB2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPHB2-001 ENSP00000383053 ENST00000400191	P29323 [Direct mapping] Ephrin type-B receptor 2 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001655 [urogenital system development] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005005 [transmembrane-ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0016021 [integral component of membrane] GO:0016310 [phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0022038 [corpus callosum development] GO:0030424 [axon] GO:0030425 [dendrite] GO:0042472 [inner ear morphogenesis] GO:0048013 [ephrin receptor signaling pathway] GO:0050878 [regulation of body fluid levels] GO:0051965 [positive regulation of synapse assembly] GO:0060021 [palate development] GO:0060996 [dendritic spine development] GO:0060997 [dendritic spine morphogenesis] GO:0071679 [commissural neuron axon guidance] Show all	1055 aa 117.5 kDa	Yes	2
EPHB2-002 ENSP00000363763 ENST00000374632	P29323 [Direct mapping] Ephrin type-B receptor 2 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001655 [urogenital system development] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005005 [transmembrane-ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0016021 [integral component of membrane] GO:0016310 [phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0022038 [corpus callosum development] GO:0030424 [axon] GO:0030425 [dendrite] GO:0042472 [inner ear morphogenesis] GO:0048013 [ephrin receptor signaling pathway] GO:0050878 [regulation of body fluid levels] GO:0051965 [positive regulation of synapse assembly] GO:0060021 [palate development] GO:0060996 [dendritic spine development] GO:0060997 [dendritic spine morphogenesis] GO:0071679 [commissural neuron axon guidance] Show all	987 aa 110 kDa	Yes	2
EPHB2-003 ENSP00000363761 ENST00000374630	P29323 [Direct mapping] Ephrin type-B receptor 2 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001655 [urogenital system development] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005005 [transmembrane-ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0016021 [integral component of membrane] GO:0016310 [phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0022038 [corpus callosum development] GO:0030424 [axon] GO:0030425 [dendrite] GO:0042472 [inner ear morphogenesis] GO:0048013 [ephrin receptor signaling pathway] GO:0050878 [regulation of body fluid levels] GO:0051965 [positive regulation of synapse assembly] GO:0060021 [palate development] GO:0060996 [dendritic spine development] GO:0060997 [dendritic spine morphogenesis] GO:0071679 [commissural neuron axon guidance] Show all	986 aa 109.9 kDa	Yes	2
EPHB2-004 ENSP00000363758 ENST00000374627	B1AKC9 [Direct mapping] Receptor protein-tyrosine kinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0048013 [ephrin receptor signaling pathway] Show all	946 aa 105.6 kDa	No	2
EPHB2-201 ENSP00000444174 ENST00000544305	Q6NVW1 [Direct mapping] EPHB2 protein; Ephrin type-B receptor 2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005003 [ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0048013 [ephrin receptor signaling pathway] Show all	482 aa 53.3 kDa	Yes	0

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