Tissue expression of PDE6B - Summary - The Human Protein Atlas

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PDE6B

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PDE6B
Gene description	Phosphodiesterase 6B, cGMP-specific, rod, beta
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (hippocampus)
FANTOM5:	Tissue enriched (retina)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in photoreceptor cells.

DATA RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Supported based on 2 antibodies. HPA054148 , HPA059929
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Eye

N/A

Retina

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hippocampus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (retina)

GENE INFORMATION
Gene name	PDE6B (HGNC Symbol)
Synonyms	CSNB3, CSNBAD2, PDEB, rd1, RP40
Description	Phosphodiesterase 6B, cGMP-specific, rod, beta (HGNC Symbol)
Entrez gene summary	Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	625584 - 670782
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133256 (version 83.38)
Entrez gene	5158
UniProt	P35913 (UniProt - Evidence at protein level)
neXtProt	NX_P35913
Antibodypedia	PDE6B antibodies

PROTEIN BROWSER

PDE6B-001	PDE6B-002	PDE6B-003	PDE6B-006	PDE6B-007	PDE6B-008	PDE6B-011	PDE6B-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDE6B-001 ENSP00000255622 ENST00000255622	P35913 [Direct mapping] Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Show all	Enzymes ENZYME proteins Hydrolases Phobius predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008081 [phosphoric diester hydrolase activity] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0046037 [GMP metabolic process] GO:0046872 [metal ion binding] GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] GO:0051480 [cytosolic calcium ion homeostasis] GO:0097381 [photoreceptor disc membrane] Show all	853 aa 98.2 kDa	No	0
PDE6B-002 ENSP00000420295 ENST00000496514	P35913 [Direct mapping] Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Show all	Enzymes ENZYME proteins Hydrolases Phobius predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001750 [photoreceptor outer segment] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008081 [phosphoric diester hydrolase activity] GO:0009583 [detection of light stimulus] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0046037 [GMP metabolic process] GO:0046872 [metal ion binding] GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] GO:0051480 [cytosolic calcium ion homeostasis] GO:0060041 [retina development in camera-type eye] GO:0097381 [photoreceptor disc membrane] Show all	854 aa 98.3 kDa	No	0
PDE6B-003 ENSP00000406334 ENST00000429163	P35913 [Direct mapping] Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Show all	Enzymes ENZYME proteins Hydrolases Phobius predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008081 [phosphoric diester hydrolase activity] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0046037 [GMP metabolic process] GO:0046872 [metal ion binding] GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] GO:0051480 [cytosolic calcium ion homeostasis] GO:0097381 [photoreceptor disc membrane] Show all	575 aa 66.5 kDa	No	0
PDE6B-006 ENSP00000418256 ENST00000487902	C9J7V6 [Direct mapping] Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Show all	Predicted intracellular proteins Show all		97 aa 10.8 kDa	No	0
PDE6B-007 ENSP00000418454 ENST00000465426	C9J628 [Direct mapping] Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Show all	Predicted intracellular proteins Show all		42 aa 5 kDa	No	0
PDE6B-008 ENSP00000420228 ENST00000488061		Predicted intracellular proteins Show all		6 aa 0.8 kDa	No	0
PDE6B-011 ENSP00000417852 ENST00000471824	H7C4P9 [Direct mapping] Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Show all	Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0007165 [signal transduction] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	144 aa 16.9 kDa	No	0
PDE6B-012 ENSP00000417178 ENST00000461490	H7C4F7 [Direct mapping] Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Show all	Predicted intracellular proteins Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0007165 [signal transduction] GO:0008152 [metabolic process] Show all	149 aa 17.4 kDa	No	0

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The Human Protein Atlas

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