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LARS

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GENERAL INFORMATION

Gene name

 LARS

Gene description

 Leucyl-tRNA synthetase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the nuclear bodies.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Nuclear bodies (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by custom assay

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA036424 , HPA040881
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the nuclear bodies.

Main location

 Cytosol (supported)

Additional location

 Nuclear bodies (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA036424 A-431 Nuclear bodies
Cytosol
HPA036424 U-2 OS Nuclear bodies
Cytosol
HPA036424 U-251 MG Nuclear bodies
Cytosol
HPA040881 A-431 Nuclear bodies
Cytosol
HPA040881 U-2 OS Cytosol Intensity Intensity
HPA040881 U-251 MG Cytosol

CUSTOM DATA

 

 

 
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Thumbnail

Antibody

Cell line

Assay

Description
HPA040881 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. LARS is mostly expressed during S and/or G2.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to custom assay

Intensity variation

 Cytosol

GENE INFORMATION

Gene name

 LARS (HGNC Symbol)

Synonyms

 FLJ10595, FLJ21788, HSPC192, LARS1, LEUS, RNTLS

Description

 Leucyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q32

Chromosome location (bp)

 146113038 - 146182660

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133706 (version 83.38)

Entrez gene

 51520

UniProt

 Q9P2J5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P2J5

Antibodypedia

 LARS antibodies

PROTEIN BROWSER
LARS-001
LARS-002
LARS-201
LARS-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LARS-001
ENSP00000377954
ENST00000394434
Q9P2J5 [Direct mapping]
Leucine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0010467 [gene expression]
Show all
 1176 aa
134.5 kDa 		No 0
LARS-002
ENSP00000426005
ENST00000510191
Q9P2J5 [Direct mapping]
Leucine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0010467 [gene expression]
Show all
 1122 aa
128 kDa 		No 0
LARS-201
ENSP00000274562
ENST00000274562
Q9P2J5 [Direct mapping]
Leucine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0010467 [gene expression]
Show all
 485 aa
55.3 kDa 		No 0
LARS-202
ENSP00000481381
ENST00000618084
A0A087WXY1 [Direct mapping]
Leucine--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
Show all
 160 aa
18.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.