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LARS

GENERAL INFORMATION

Gene name

 LARS

Gene description

 Leucyl-tRNA synthetase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA036424 , HPA040881
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and thyroid cancer (unfavourable).
Liver cancer p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036424
HPA040881

GENE INFORMATION

Gene name

 LARS (HGNC Symbol)

Synonyms

 FLJ10595, FLJ21788, HSPC192, LARS1, LEUS, RNTLS

Description

 Leucyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q32

Chromosome location (bp)

 146113038 - 146182660

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133706 (version 83.38)

Entrez gene

 51520

UniProt

 Q9P2J5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P2J5

Antibodypedia

 LARS antibodies

PROTEIN BROWSER
LARS-001
LARS-002
LARS-201
LARS-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LARS-001
ENSP00000377954
ENST00000394434
Q9P2J5 [Direct mapping]
Leucine--tRNA ligase, cytoplasmic
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0010467 [gene expression]
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 1176 aa
134.5 kDa 		No 0
LARS-002
ENSP00000426005
ENST00000510191
Q9P2J5 [Direct mapping]
Leucine--tRNA ligase, cytoplasmic
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Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0010467 [gene expression]
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 1122 aa
128 kDa 		No 0
LARS-201
ENSP00000274562
ENST00000274562
Q9P2J5 [Direct mapping]
Leucine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0010467 [gene expression]
Show all
 485 aa
55.3 kDa 		No 0
LARS-202
ENSP00000481381
ENST00000618084
A0A087WXY1 [Direct mapping]
Leucine--tRNA ligase, cytoplasmic
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
Show all
 160 aa
18.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.