Cell atlas - TRIM45 - The Human Protein Atlas

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TRIM45

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytokinetic bridge
	Cytosol

Human cell
	Cytosol
	Microtubules

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GENERAL INFORMATION
Gene name	TRIM45
Gene description	Tripartite motif containing 45
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the cytokinetic bridge.
RNA cell category	Cell line enhanced (RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Cytokinetic bridge (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA054308
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the cytokinetic bridge.

Main location

Cytosol (supported)

Additional location

Cytokinetic bridge (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA054308	MCF7	Nucleoplasm
	HPA054308	MCF7	Cytosol
	HPA054308	U-2 OS	Cytokinetic bridge	Intensity	Intensity
	HPA054308	U-2 OS	Cytosol
	HPA054308	U-251 MG	Cytosol

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	TRIM45 (HGNC Symbol)
Synonyms	FLJ13181, RNF99
Description	Tripartite motif containing 45 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Chromosome	1
Cytoband	p13.1
Chromosome location (bp)	117111060 - 117122587
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134253 (version 83.38)
Entrez gene	80263
UniProt	Q9H8W5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H8W5
Antibodypedia	TRIM45 antibodies

PROTEIN BROWSER

TRIM45-001	TRIM45-002	TRIM45-003	TRIM45-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIM45-001 ENSP00000256649 ENST00000256649	Q9H8W5 [Direct mapping] Tripartite motif-containing protein 45 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0045171 [intercellular bridge] GO:0046872 [metal ion binding] GO:0060348 [bone development] Show all	580 aa 64.4 kDa	No	0
TRIM45-002 ENSP00000358476 ENST00000369464	Q9H8W5 [Direct mapping] Tripartite motif-containing protein 45 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0045171 [intercellular bridge] GO:0046872 [metal ion binding] Show all	562 aa 62.5 kDa	No	0
TRIM45-003 ENSP00000358473 ENST00000369461	Q5T2K3 [Direct mapping] Tripartite motif-containing protein 45 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] Show all	523 aa 58.2 kDa	No	0
TRIM45-004 ENSP00000474935 ENST00000485032	S4R407 [Direct mapping] Tripartite motif-containing protein 45 Show all	Predicted intracellular proteins Show all	GO:0005622 [intracellular] GO:0008270 [zinc ion binding] Show all	303 aa 34.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.